134556-80-2Relevant academic research and scientific papers
Isolation of an isomer of FK-506 from fermentation of Streptomyces tsukubaensis and its chemical synthesis from FK-506
Grassberger, Maximilian A.,Fehr, Theodor,Horvath, Amarylla,Schulz, Gerhard
, p. 413 - 430 (2007/10/02)
From the fermentation broth of Streptomyces tsukubaensis 9993 an isomer 2a of the immunosuppressant FK-506 1a was isolated as a minor metabolite. From NMR- and FAB-MS data follows that in 2a the size of the macrocycle is reduced by two carbon atoms due to
