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104987-25-9

104987-25-9

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104987-25-9 Usage

Uses

33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate in the synthesis of Iso-FK-506 (iso-Tacrolimus) (I816250), which is an isomer of FK-506 (F370000) from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent.

Check Digit Verification of cas no

The CAS Registry Mumber 104987-25-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,9,8 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 104987-25:
(8*1)+(7*0)+(6*4)+(5*9)+(4*8)+(3*7)+(2*2)+(1*5)=139
139 % 10 = 9
So 104987-25-9 is a valid CAS Registry Number.

104987-25-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 33-O-tert.butyldimethylsilyl-FK-506

1.2 Other means of identification

Product number -
Other names 33-OTBDMS-FK506

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104987-25-9 SDS

104987-25-9Relevant articles and documents

Isolation of an isomer of FK-506 from fermentation of Streptomyces tsukubaensis and its chemical synthesis from FK-506

Grassberger, Maximilian A.,Fehr, Theodor,Horvath, Amarylla,Schulz, Gerhard

, p. 413 - 430 (2007/10/02)

From the fermentation broth of Streptomyces tsukubaensis 9993 an isomer 2a of the immunosuppressant FK-506 1a was isolated as a minor metabolite. From NMR- and FAB-MS data follows that in 2a the size of the macrocycle is reduced by two carbon atoms due to

C10 N-Acyl modified KY-506: A possible hybrid analogue of the transition state of peptidyl-prolyl cis-trans isomerization

Donald,Cooper,Furber,Wells,Hutchinson,Black

, p. 1375 - 1378 (2007/10/02)

Three C 10 N-Acyl derivatives of FK-506 have been prepared. The reduced receptor binding of these analogues is not consistent with a direct overlap of FK-506 and a peptide substrate.

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