104987-25-9 Usage
Uses
Used in Pharmaceutical Industry:
33-O-tert-butyldimethylsilyl-FK-506 is used as an intermediate in the synthesis of Iso-FK-506 (iso-Tacrolimus) for its immunosuppressant and anti-inflammatory properties. This application is significant in the development of medications that help manage and treat various autoimmune and inflammatory conditions.
Used in Immunosuppressant Applications:
33-O-tert-butyldimethylsilyl-FK-506 contributes to the creation of Iso-FK-506, which acts as an immunosuppressant. It is particularly useful in preventing organ transplant rejection and managing autoimmune diseases by suppressing the immune system's response.
Used in Anti-inflammatory Applications:
The compound is also used in the development of anti-inflammatory agents. Iso-FK-506, synthesized using 33-O-tert-butyldimethylsilyl-FK-506, helps in reducing inflammation and alleviating the symptoms associated with various inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 104987-25-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,9,8 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 104987-25:
(8*1)+(7*0)+(6*4)+(5*9)+(4*8)+(3*7)+(2*2)+(1*5)=139
139 % 10 = 9
So 104987-25-9 is a valid CAS Registry Number.
104987-25-9Relevant academic research and scientific papers
Isolation of an isomer of FK-506 from fermentation of Streptomyces tsukubaensis and its chemical synthesis from FK-506
Grassberger, Maximilian A.,Fehr, Theodor,Horvath, Amarylla,Schulz, Gerhard
, p. 413 - 430 (2007/10/02)
From the fermentation broth of Streptomyces tsukubaensis 9993 an isomer 2a of the immunosuppressant FK-506 1a was isolated as a minor metabolite. From NMR- and FAB-MS data follows that in 2a the size of the macrocycle is reduced by two carbon atoms due to
Highly selective reactions of FK506 with diazomethane
Edmunds,Baumann,Grassberger,Schulz
, p. 7039 - 7042 (2007/10/02)
Three modes of diazomethane reactivity, namely oxirane formation, O-methylation and cyclopropanation, can be accomplished with excellent selectivity on the multifunctional molecule FK506.
C10 N-Acyl modified KY-506: A possible hybrid analogue of the transition state of peptidyl-prolyl cis-trans isomerization
Donald,Cooper,Furber,Wells,Hutchinson,Black
, p. 1375 - 1378 (2007/10/02)
Three C 10 N-Acyl derivatives of FK-506 have been prepared. The reduced receptor binding of these analogues is not consistent with a direct overlap of FK-506 and a peptide substrate.
