118949-52-3

Basic information

• Product Name: 22(S)-dihydro-FK-506
• CAS NO: 118949-52-3
• Molecular Weight: 806.047
• Mol File: 118949-52-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 22(S)-dihydro-FK-506(CAS DataBase Reference)
• NIST Chemistry Reference: 22(S)-dihydro-FK-506(118949-52-3)
• EPA Substance Registry System: 22(S)-dihydro-FK-506(118949-52-3)

Safety Data

• Hazardous Substances Data: 118949-52-3(Hazardous Substances Data)

Upstream product

• 134556-80-2 33-O-tert-butyldimethylsilyl-22(S)-dihydro-FK-506 
• 104987-25-9 33-O-tert.butyldimethylsilyl-FK-506 
• 133523-46-3 C₄₈H₇₈BNO₁₂ 
• 104987-11-3 Tacrolimus 
• 118949-53-4 C₈₀H₁₅₇NO₁₂Si₅ 
• 118949-51-2 C₇₄H₁₄₃NO₁₂Si₄ 
• 118949-51-2 C₇₄H₁₄₃NO₁₂Si₄ 
• 118977-95-0 C₇₄H₁₃₉NO₁₂Si₄ 
• 118977-95-0 C₇₄H₁₃₉NO₁₂Si₄ 

Downstream Products

• 126789-47-7 C₅₆H₉₉NO₁₂Si₂ 
• 124093-25-0 C₄₅H₇₅NO₁₃ 
• 124093-24-9 (3R,5S,6R)-6-[(5E,13E)-(1S,3S,7R,8S,10S,11R,12S)-7-Allyl-8,10,12-trihydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-tetradeca-5,13-dienyl]-5-methoxy-3-methyl-tetrahydro-pyran-2-one 
• 134556-82-4 C₄₄H₇₁NO₁₂ 
• 124125-41-3 C₄₄H₇₀INO₁₂ 
• 124093-23-8 C₄₅H₇₃NO₁₃ 
• 133523-45-2 (10E,18E)-(2R,4S,5R,6S,8S,12R,13S,15S,16R,17S)-12-Allyl-5,13,15,17-tetrahydroxy-19-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-4,6-dimethoxy-2,8,10,16,18-pentamethyl-nonadeca-10,18-dienoic acid methyl ester 

Relevant articles and documents

Isolation of an isomer of FK-506 from fermentation of Streptomyces tsukubaensis and its chemical synthesis from FK-506

From the fermentation broth of Streptomyces tsukubaensis 9993 an isomer 2a of the immunosuppressant FK-506 1a was isolated as a minor metabolite. From NMR- and FAB-MS data follows that in 2a the size of the macrocycle is reduced by two carbon atoms due to

Chemistry of tricarbonyl hemiketals and application of Evans' technology to the total synthesis of the immunosuppressant (-)-FK-506

Details of model studies probing the chemistry of the tricarbonyl region of FK-506 are presented, and their use in designing a successful route to this immunosuppressant is outlined. Application of asymmetric oxazolidinone alkylation/aldol methodology to a convergent, highly flexible synthesis of the C10-C18 fragment and to improvements in the preparation of the C20-C34 segment are also discussed.

Total Synthesis of the Immunosuppressant (-)-FK-506

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