1345817-45-9

Upstream product

• 177895-59-9 (1S,4R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-en-1-yl pivalate 
• 178034-11-2 (3R,5S)-(+)-3-acetoxy-5-(trimethylacetyloxy)cyclopent-1-ene 
• 178034-12-3 (1S,4R)-4-hydroxycyclopent-2-enyl 2,2,2-trimethylacetate 
• 104069-09-2 (1S,4R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enol 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 1345817-44-8 (1R,2S)-2-((S,E)-3-((benzyloxy)methoxy)oct-1-en-1-yl)cyclopent-3-enol 
• 100-39-0 benzyl bromide 
• 1345817-43-7 C₂₇H₄₄O₃Si 
• 1345817-42-6 (S,E)-1-((1S,5R)-5-((tert-butyldimethylsilyl)oxy)cyclopent-2-en-1-yl)oct-1-en-3-ol 
• 1345817-41-5 (S)-1-((1S,5R)-5-((tert-butyldimethylsilyl)oxy)cyclopent-2-en-1-yl)oct-1-yn-3-ol 
• 1345817-40-4 C₁₉H₃₂O₂Si 
• 1345817-39-1 C₁₉H₃₄O₂Si 
• 1345817-38-0 tert-butyl(((1R,2S)-2-ethynylcyclopent-3-en-1-yl)oxy)dimethylsilane 
• 1345817-37-9 C₁₆H₃₀OSi₂ 

Relevant academic research and scientific papers

Allylic substitution on cyclopentene and -hexene rings with alkynylcopper reagents

Substitution of cyclic allylic picolinates with a reagent derived from TMS-C≡CMgBr and a copper salt was investigated. Although the previous type of reagent (TMSC≡CMgBr and CuBr?Me2S) developed for linear allylic picolinates was less product selective and regioselective, the Cu(acac)2-derived reagent was highly selective (94-95%) to afford the SN2′ product in good yields. As an application, several C-C bond formations at the acetylenic carbon and the synthesis of the PG intermediate were studied with success.