134582-17-5Relevant academic research and scientific papers
A new application of Candida Antarctica lipase for obtaining natural homochiral BBAs aryloxypropanolamine
Bermudez, Jose L.,Del Campo, Carmen,Salazar, Loreto,Llama, Emilio F.,Sinisterra, Jose V.
, p. 2485 - 2488 (1996)
CAL offers increased ee, together with broad substrate structural tolerance that makes it a firm candidate for the resolution of BBAs of type 1.
Diplogelasinospora grovesii IMI 171018, a new whole cell biocatalyst for the stereoselective reduction of ketones
Carballeira, Jose D.,Alvarez, Emilio,Campillo, Mercedes,Pardo, Leonardo,Sinisterra, Jose V.
, p. 951 - 962 (2004)
A screening of 416 strains (71 bacterial strains, 45 actinomycetes, 59 yeast, 60 basidiomycetes, 33 marine fungi and 148 filamentous fungi) has been performed to look for microorganisms that display reductase activity in the absence of oxidase activity. A new microorganism, Diplogelasinospora grovesii IMI 171018 (a nonpathogen strain), was isolated and showed very high activity and stereoselectivity in the reduction of cyclic ketones. The fungus was selected due to its selectivity towards monocyclic and bicyclic ketones and its easy culture conditions, which allow an easy scale-up. D. grovesii is more active in the reduction of conventional ketones than S. cerevisiae type II (from Sigma) and can work in the presence of high ketone concentrations (2 = 0.549) and can be used to explain and to predict the structure of ketones that can or cannot be reduced by this microorganism.
Highly stereoselective reduction of haloketones using three new yeasts: Application to the synthesis of (S)-adrenergic β-blockers related to propranolol
Martinez Lagos, Fernando,Carballeira, Jose D.,Bermudez, Jose L.,Alvarez, Emilio,Sinisterra, Jose V.
, p. 763 - 770 (2007/10/03)
The stereoselective reduction of aryloxy-halo-2-propanones 1 or of 1-chloro-3(phthalimdyl)-propan-2-one 2 using baker's yeast usually displays poor yields and/or ees. Three new yeasts, Saccharomyces bayanus CECT 1317, Yarrowia lipolytica CECT 1240 and Pic
Enzyme Assisted Preparation of Enantiomerically Pure β-Adrenergic Blockers III. Optically Active Chlorohydrin Derivatives and Their Conversion
Ader, Ulrich,Schneider, Manfred P.
, p. 521 - 524 (2007/10/02)
Optical active chlorohydrin derivatives 2a-m and 3a-m of both enantiomeric series were prepared via both enzymatic hydrolyses and acyltransfer reactions catalysed by a highly selective lipase from Pseudomonas sp..The resulting building blocks were further transformed into the corresponding β-blockers of high enantiomeric purity.
