1346015-59-5

Upstream product

• 159188-33-7 5,7-dimethoxy-2-phenylquinoline-4(1H)-one 
• 380501-39-3 N-(2-acetyl-3,5-dimethoxy-phenyl)-benzamide 
• 94088-74-1 N-(3,5-dimethoxyphenyl)benzamide 
• 10272-07-8 3.5-dimethoxyaniline 
• 98-88-4 benzoyl chloride 
• 288-32-4 1H-imidazole 
• 1156271-96-3 4-chloro-5,7-dimethoxy-2-phenylquinoline 

Relevant academic research and scientific papers

Synthesis and antitumor activity of novel 4-aminoquinoline derivatives

A series of novel 4-aminoquinoline derivatives were synthesized as antitumor agents by reacting 4-chloroquinoline with the corresponding mono/dialkyl amines. The cytotoxicity of these compounds was evaluated in vitro against HCT-116, A549, DU-145, HepG2, and LN229 cell lines. The results showed that most of the synthesized compounds displayed excellent cytotoxicity, and 5,7-dimethoxy-2-phenyl-N-propylquinoline-4-amine (6a) displayed the most potent cytotoxicity against HCT-116 cells. Furthermore, 6a could decrease VEGF protein expression.