1156271-96-3

Upstream product

• 98-88-4 benzoyl chloride 
• 10272-07-8 3.5-dimethoxyaniline 
• 94088-74-1 N-(3,5-dimethoxyphenyl)benzamide 
• 380501-39-3 N-(2-acetyl-3,5-dimethoxy-phenyl)-benzamide 
• 159188-33-7 5,7-dimethoxy-2-phenylquinoline-4(1H)-one 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 829-20-9 2',4'-dimethoxyacetophenone 

Downstream Products

• 1346015-66-4 5,7-dimethoxy-2-phenyl-N-propylquinoline-4-amine 
• 1346015-58-4 N-butyl-5,7-dimethoxy-2-phenylquinoline-4-amine 
• 1346015-59-5 4-(1H-imidazole-1-yl)-5,7-dimethoxy-2-phenylquinoline 
• 1346015-60-8 5,7-dimethoxy-2-phenyl-4-(piperidin-1-yl)quinoline 
• 1346015-61-9 5,7-dimethoxy-4-morpholino-2-phenylquinoline 
• 1346015-62-0 5,7-dimethoxy-4-(4-methylpiperazin-1-yl)-2-phenylquinoline 
• 1346015-63-1 N-cyclohexyl-5,7-dimethoxy-2-phenylquinoline-4-amine 
• 1346015-64-2 5,7-dimethoxy-N,2-diphenylquinoline-4-amine 
• 1346015-65-3 N-benzyl-5,7-dimethoxy-2-phenylquinoline-4-amine 

Relevant academic research and scientific papers

Weakly Coordinating, Ketone-Directed (η5-Pentamethylcyclopentadienyl)cobalt(III)- and (η5-Pentamethylcyclopentadienyl)rhodium(III)-Catalyzed C?H Amidation of Arenes: A Route to Acridone Alkaloids

The weakly coordinating, ketone-directed, regioselective monoamidation of aromatic ketones, chalcone, carbazole, and benzophenones was achieved by employing high-valent cobalt and rhodium catalysis to access numerous biologically important molecular building blocks. This amidation proceeded smoothly with a variety of ketones and several amidating partners. The application of the products in the synthesis of various heterocycles, including acridones, indoles, quinoline, quinolones, quinolinones, and quinazolines, was also explored. The total synthesis of acridone-based alkaloids, namely, toddaliopsin A, toddaliopsin D, and arborinine, and the formal synthesis of acronycine and noracronycin were also accomplished by applying this method. A mechanistic study revealed this amidation reaction follows a base-assisted intermolecular electrophilic substitution pathway.

Synthesis and antitumor activity of novel 4-aminoquinoline derivatives

A series of novel 4-aminoquinoline derivatives were synthesized as antitumor agents by reacting 4-chloroquinoline with the corresponding mono/dialkyl amines. The cytotoxicity of these compounds was evaluated in vitro against HCT-116, A549, DU-145, HepG2, and LN229 cell lines. The results showed that most of the synthesized compounds displayed excellent cytotoxicity, and 5,7-dimethoxy-2-phenyl-N-propylquinoline-4-amine (6a) displayed the most potent cytotoxicity against HCT-116 cells. Furthermore, 6a could decrease VEGF protein expression.