1346163-23-2

Basic information

• Product Name: (1S,2S,6R,7aR)-1,6-dihydroxy-2-(4-hydroxybenzyl)tetrahydro-1H-pyrrolizin-3(2H)-one
• Synonyms: (1S,2S,6R,7aR)-1,6-dihydroxy-2-(4-hydroxybenzyl)tetrahydro-1H-pyrrolizin-3(2H)-one
• CAS NO: 1346163-23-2
• Molecular Weight: 263.293
• Mol File: 1346163-23-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2S,6R,7aR)-1,6-dihydroxy-2-(4-hydroxybenzyl)tetrahydro-1H-pyrrolizin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,6R,7aR)-1,6-dihydroxy-2-(4-hydroxybenzyl)tetrahydro-1H-pyrrolizin-3(2H)-one(1346163-23-2)
• EPA Substance Registry System: (1S,2S,6R,7aR)-1,6-dihydroxy-2-(4-hydroxybenzyl)tetrahydro-1H-pyrrolizin-3(2H)-one(1346163-23-2)

Safety Data

• Hazardous Substances Data: 1346163-23-2(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 2584-71-6 cis-hydroxy-D-proline 
• 192320-50-6 tert-butyl (2S,4R)-2-formyl-4-hydroxypyrrolidine-1-carboxylate 
• 37813-30-2 (2S,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester 
• 77450-00-1 (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 77449-99-1 (2R,4R)-2-ethoxycarbonyl-4-hydroxypyrrolidine hydrochloride 
• 540-38-5 p-Iodophenol 
• 1346163-19-6 (1S,6R,7aR,,Z)-1,6-dihydroxy-2-(4-hydroxybenzylidene)tetrahydro-1H-pyrrolizin-3(2H)-one 
• 1346163-15-2 (1S,6R,7aR)-1,6-dihydroxy-2-methylenetetrahydro-1H-pyrrolizin-3(2H)-one 
• 1346163-13-0 tert-butyl (2R,4R)-4-hydroxy-2-[(1S)-1-hydroxy-3-methoxy-2-methylidene-3-oxopropyl]pyrrolidine-1-carboxylate 

Downstream Products

• 1346163-24-3 (1S,2R,6R,7aR)-2-(4-hydroxybenzyl)hexahydro-1H-pyrrolizine-1,6-diol 

Relevant articles and documents

Heck reaction on morita-baylis-hillman adducts: Diastereoselective synthesis of pyrrolizidinones and pyrrolizidines

An efficient approach to the diastereoselective synthesis of benzylidene-, benzyl-pyrrolizidinones, and pyrrolizidines is described. The sequence is based on a highly stereoselective Heck reaction between a hydroxylated pyrrolizidinone, prepared from a Morita-Baylis-Hillman adduct, and a suitable aryl halide, using Nájeras oxime derived palladacycle as catalyst. Georg Thieme Verlag Stuttgart - New York.