1346459-83-3

Upstream product

• 651-83-2 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline 
• 71381-91-4 (+/-)-2-(4-isobutylphenyl)propanoyl chloride 
• 1346459-76-4 2-(4-isobutylphenyl)-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide 
• 780-69-8 triethoxyphenylsilane 
• 434-64-0 perfluorotoluene 
• 15687-27-1 ibuprofen 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 

Relevant academic research and scientific papers

An Epoxide-Mediated Deprotection Method for Acidic Amide Auxiliary

A practical method for the removal of a versatile acidic amide auxiliary has been developed. Facile alcoholysis of the amide in the presence of KOAc is enabled by an epoxide, which mechanistically resembles the removal of the Myers' auxiliary. The protocol has been applied to the removal of a variety of amide substrates and their C-H functionalization products with high efficiency and low cost, representing a step forward toward the development of a versatile directing group for C-H activation.

Ligand-Enabled Cross-Coupling of C(sp3)-H Bonds with Arylsilanes

Pd(II)-catalyzed cross-coupling of C(sp3)-H bonds with organosilicon coupling partners has been achieved for the first time. The use of a newly developed quinoline-based ligand is essential for the cross-coupling reactions to proceed.

Pd(II)-catalyzed cross-coupling of C(sp2)h bonds and alkyl, aryl, and vinylboron reagents via Pd(II)/Pd(0) catalysis

Pd(II)-catalyzed cross-coupling of ortho-CH bonds in benzoic acid and phenylacetic acid amides with alkyl, aryl, and vinylboron reagents have been achieved via Pd(II)/Pd(0) catalysis, demonstrating the unprecedented versatility of CH activation reactions.