13466-31-4Relevant articles and documents
TEMPO-mediated Aza-diels-alder reaction: Synthesis of tetrahydropyridazines using ketohydrazones and olefins
Yang, Xiu-Long,Peng, Xie-Xue,Chen, Fei,Han, Bing
supporting information, p. 2070 - 2073 (2016/06/09)
A novel, facile, and efficient method for the synthesis of tetrahydropyridazines by a one-pot tandem reaction of easily accessible ketohydrazones and olefins in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) has been successfully developed. The reaction involves the initial generation of azoalkenes from direct oxidative dehydrogenation of ketohydrazones using TEMPO as the commercially available oxidant, followed by a subsequent aza-Diels-Alder reaction with olefins.
Synthesis of a new class of bis(thiourea)hydrazide pseudopeptides as potential inhibitors of β-sheet aggregation
Klein, Jan J.,Hecht, Stefan
supporting information; experimental part, p. 330 - 333 (2012/02/04)
The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display "amphifinity", i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.
Intermolecular Cope-type hydroamination of alkynes using hydrazines
Cebrowski, Pamela H.,Roveda, Jean-Gregoire,Moran, Joseph,Gorelsky, Serge I.,Beauchemin, Andre M.
, p. 492 - 493 (2008/09/20)
Metal-free, intermolecular hydroaminations are performed upon heating aryl acetylenes and MeNHNH2 at 140°C, with preferential formation of the linear, "anti-Markovnikov" hydrazones. The Royal Society of Chemistry.