3463-26-1

Basic information

• Product Name: 1-Methyl-3-phenyl-pyrazole
• Synonyms: 1-Methyl-3-phenyl-pyrazole;1-Methyl-3-phenyl-1H-pyrazole
• CAS NO: 3463-26-1
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158
• Mol File: 3463-26-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 56°C
• Boiling Point: 280.55°C
• Flash Point: 123.4°C
• Appearance: /
• Density: 1.0232
• Vapor Pressure: 0.00641mmHg at 25°C
• Refractive Index: 1.6057 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 1.72±0.10(Predicted)
• CAS DataBase Reference: 1-Methyl-3-phenyl-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3-phenyl-pyrazole(3463-26-1)
• EPA Substance Registry System: 1-Methyl-3-phenyl-pyrazole(3463-26-1)

Safety Data

• Hazardous Substances Data: 3463-26-1(Hazardous Substances Data)

Usage

Uses

1-methyl-3-phenyl-1H-pyrazole is a useful research reagent for the synthesis of bioactive important small molecules.

Synthesis Reference(s)

The Journal of Organic Chemistry, 62, p. 8325, 1997 DOI: 10.1021/jo970897r

InChI:InChI=1/C10H10N2/c1-12-8-7-10(11-12)9-5-3-2-4-6-9/h2-8H,1H3

Upstream product

• 51772-25-9 1,2-dimethyl-3-phenyl-pyrazolium; iodide 
• 57623-20-8 3-benzoyloxy-1-phenyl-propenone 
• 60-34-4 methylhydrazine 
• 3506-51-2 Benzoyl acetaldehyde 
• 13466-29-0 benzaldehyde N-methyl hydrazone 
• 107-06-2 1,2-dichloro-ethane 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 6939-12-4 N-methylsydnone 
• 536-74-3 phenylacetylene 
• 18076-03-4 1-methyl 3-phenyl Δ²-pyrazoline 
• 13466-31-4 1-benzyl-1-methyl-2-(1-phenylethylidene)hydrazine 
• 1402242-69-6 potassium trifluoro(1-methyl-3-phenyl-1H-pyrazol-5-yl)borate 
• 1402242-70-9 potassium trifluoro(1-methyl-5-phenyl-1H-pyrazol-3-yl)borate 
• 2458-26-6 3-phenylpyrazole 

Downstream Products

• 51772-25-9 1,2-dimethyl-3-phenyl-pyrazolium; iodide 
• 105994-55-6 4-bromo-1-methyl-3-phenyl-1H-pyrazole 
• 85302-22-3 (1-methyl-3-phenyl-1H-pyrazol-4-yl)phenylmethanone 
• 105994-56-7 1-methyl-3-phenyl-1H-pyrazole-4-carboxylic acid 
• 66129-68-8 1-Methyl-3-phenyl-1H-pyrazole-4-carbonyl chloride 
• 105994-77-2 4-bromo-1-methyl-5-phenyl-1H-pyrazole 
• 1345118-52-6 C₁₀H₁₁BN₂O₂ 
• 1361379-47-6 N-(2,6-difluorophenyl) [5-(1-methyl-3-phenylpyrazol-5-yl)(2-thienyl)]carboxamide 
• 1361379-74-9 C₂₀H₁₅FN₄OS 
• 1361380-63-3 C₁₃H₁₂N₄S 
• 63637-58-1 3-phenyl-1-(4-methylphenyl)-1H-pyrazole 

Relevant articles and documents

Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C–C/C–N formation, annulation and aromatization with 1,2-dichloroethane

A novel route for tandem C–C/C–N formation, annulation and aromatization of hydrazones with 1,2-dichloroethane to synthesize 1H-pyrazoles has been developed. Furthermore, the 1,2-dichloroethane serves as alkylation reagent in good to excellent yields. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of 1H-pyrazoles.

Cu-promoted sydnone cycloadditions of alkynes: Scope and mechanism studies

Cu salts have been found to promote the cycloaddition reaction of sydnones and terminal alkynes, providing significant reduction in reaction times. Specifically, the use of Cu(OTf)2 is found to provide 1,3-disubstituted pyrazoles, whereas simpl

Synthesis of ynone trifluoroborates toward functionalized pyrazoles

The synthesis of a range of novel ynone trifluoroborates has been achieved, in a two-pot process from propargylic alcohols. These alkynes have been subsequently used in the formation of a range of pyrazole trifluoroborate salts via cyclization with hydrazines. The products are generated with high levels of regiocontrol and in excellent yields and represent versatile synthetic intermediates.