1346703-22-7 Usage
Indazole ring
A five-membered aromatic ring with three nitrogen atoms, contributing to the compound's stability and potential pharmacological activity.
Bromo group (6-position)
A bromine atom attached to the indazole ring at the 6th position, which may influence the compound's reactivity, lipophilicity, and biological activity.
Cyclopentyl substituent (1-position)
A five-carbon cyclic alkyl group attached to the nitrogen atom of the carboxamide group, which can affect the compound's solubility and steric properties.
Pyridine ring
A six-membered aromatic ring with one nitrogen atom, contributing to the compound's stability and potential pharmacological activity.
Carboxamide group
A polar functional group (-CONH2) attached to the indazole ring, which can participate in hydrogen bonding and may contribute to the compound's solubility and biological activity.
Methyl group
A small alkyl group (-CH3) attached to the pyridine ring, which can influence the compound's steric properties and lipophilicity.
Complex pyridine ring with multiple methyl and carbonyl groups
The presence of additional methyl and carbonyl groups on the pyridine ring can affect the compound's reactivity, stability, and potential applications in medicinal chemistry.
Derivative of indazole
The compound is derived from the indazole core structure, which is a common motif in biologically active molecules and may contribute to its potential applications in scientific research.
Potential applications in medicinal chemistry
Due to its complex structure and various functional groups, 1H-Indazole-4-carboxamide, 6-bromo-1-cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]may have potential applications in the development of new drugs or as a research tool in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1346703-22-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,7,0 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1346703-22:
(9*1)+(8*3)+(7*4)+(6*6)+(5*7)+(4*0)+(3*3)+(2*2)+(1*2)=147
147 % 10 = 7
So 1346703-22-7 is a valid CAS Registry Number.
1346703-22-7Relevant academic research and scientific papers
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
Kuntz, Kevin W.,Campbell, John E.,Keilhack, Heike,Pollock, Roy M.,Knutson, Sarah K.,Porter-Scott, Margaret,Richon, Victoria M.,Sneeringer, Chris J.,Wigle, Tim J.,Allain, Christina J.,Majer, Christina R.,Moyer, Mikel P.,Copeland, Robert A.,Chesworth, Richard
, p. 1556 - 1564 (2016/03/05)
Posttranslational methylation of histones plays a critical role in gene regulation. Misregulation of histone methylation can lead to oncogenic transformation. Enhancer of Zeste homologue 2 (EZH2) methylates histone 3 at lysine 27 (H3K27) and abnormal methylation of this site is found in many cancers. Tazemetostat, an EHZ2 inhibitor in clinical development, has shown activity in both preclinical models of cancer as well as in patients with lymphoma or INI1-deficient solid tumors. Herein we report the structure-activity relationships from identification of an initial hit in a high-throughput screen through selection of tazemetostat for clinical development. The importance of several methyl groups to the potency of the inhibitors is highlighted as well as the importance of balancing pharmacokinetic properties with potency.
