1346756-96-4

Basic information

• Product Name: C₁₇H₁₄ClNO
• CAS NO: 1346756-96-4
• Molecular Weight: 283.757
• Mol File: 1346756-96-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₄ClNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₄ClNO(1346756-96-4)
• EPA Substance Registry System: C₁₇H₁₄ClNO(1346756-96-4)

Safety Data

• Hazardous Substances Data: 1346756-96-4(Hazardous Substances Data)

Upstream product

• 1406071-48-4 C₁₇H₁₅NO₂ 
• 100-39-0 benzyl bromide 
• 13720-90-6 4-oxo-1,4-dihydroquinoline-2-carboxylic acid ethyl ester 

Downstream Products

• 1346756-97-5 2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one 

Relevant articles and documents

Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells

Oxidative stress is widely recognized as being associated with a number of disorders, including metabolic dysfunction and atherosclerosis. A series of substituted 4-quinolone derivatives were prepared and evaluated as inhibitors of reactive oxygen species (ROS) production from human umbilical vein endothelial cells (HUVECs). One compound in particular, 2-({[4-(3-hydroxy-3-methylbutoxy) pyridin-2-yl]oxy}methyl)-3-methylquinolin-4(1H)-one (25b), inhibited ROS production from HUVECs with an IC50 of 140 nM. This compound also exhibited low CYP2D6 inhibitory activity, high aqueous solubility, and good in vitro metabolic stability. An in vivo pharmacokinetic study of this compound in SD rats revealed high oral bioavailability and a long plasma half-life.