134682-32-9Relevant academic research and scientific papers
Synthesis of α,α-difluoro-γ-butyrolactones via ethyl iododifluoroacetate
Xiao, Fanhua,Wu, Fanhong,Shen, Yongjia,Zhou, Lifang
, p. 63 - 67 (2005)
A novel synthesis of α,α-difluoro-γ-butyrolactones was realized by the alkaline hydrolysis of the adducts of ethyl iododifluoroacetate and alkenes. Ethyl iododifluoroacetate reacted with alkenes in the presence of sodium dithionite to give the addition pr
Intermolecular Iodofluoroalkylation of Unactivated Alkynes and Alkenes Mediated by Manganese Catalysts
Bi, Qirui,Guo, Wei-Si,Ji, Yun-Xing,Wang, Lu-Jun,Zhang, Bo
supporting information, (2020/02/05)
An approach for iodofluoroalkylation of unactivated alkynes and alkenes facilitated by an earth-abundant and inexpensive manganese catalyst, Mn2(CO)10, is reported. This protocol employs visible light as the energy input and shows a wide substrate scope and high functional-group compatibility. A variety of synthetically useful fluoroalkylated alkyl and alkenyl iodides can be prepared in moderate to excellent yields. The reaction features high efficiency, operational simplicity, scalability, as well as excellent chemo-, regio-, and E/Z selectivities. (Figure presented.).
A convenient AIBN-initiated radical addition of ethyl iododifluoroacetate to alkenes
Leung, Leo,Linclau, Bruno
experimental part, p. 986 - 990 (2009/04/04)
The AIBN-initiated addition of ethyl 4-iodo-2,2-difluoroacetate to a variety of alkene substrates is described. The addition generally led to the corresponding addition products in good to excellent yields and various functional groups could be tolerated
A New Approach to α,α-Difluoro-Functionalized Esters
Yang, Zhen-Yu,Burton, Donald J.
, p. 5125 - 5132 (2007/10/02)
The addition reaction of iododifluoroacetates to alkenes is initiated by copper powder (10-20 mol percent) at 50-60 deg C.Both terminal and internal alkenes give good yields of adducts.The reaction is also applicable to alkenes containing a variety of functional groups, such as epoxy, hydroxy, ketone, ester, and phosphonate moieties.This reaction can be carried out either neat or in solvents such as hexane, benzene, acetonitrile, DMF, DMSO, and HMPA and is suppressed by p-dinitrobenzene and di-tert-butyl nitroxide.A single electron transfer initiated radical mechanism isproposed.In the presence of nickel dichloride hexahydrate, reduction of the adducts with zinc in moist THF provides the corresponding α,α-difluoro esters in good yields.
