134699-74-4Relevant articles and documents
Iridium-Catalyzed Asymmetric Hydrogenation of Sterically Hindered Cyclic Imines for Enantioselective Synthesis of Tetrahydroisoquinolines
Li, Bin,Liu, Ruixia,Yang, Jing,Luo, Jingyuan,Yao, Lin,Li, Muqiong,Zheng, Xiaohui,Jiang, Ru,Nie, Huifang,Zhang, Shengyong
supporting information, p. 140 - 144 (2021/01/13)
An efficient enantioselective hydrogenation of sterically hindered cyclic imines catalyzed by the Ir-tBu-ax-Josiphos complex has been described, producing a series of useful chiral bulky tetrahydroisoquinoline analogs in high isolated yields (85-96%) with good to excellent enantioselectivities (74-99% ee). This transformation provided highly straightforward access to the useful derivatives of tetrahydroisoquinolines, which are of great potential value in drug molecule and natural product research.
