13471-34-6

Basic information

• Product Name: N¹,N²-di(p-tolyl)benzamidine
• Synonyms: N¹,N²-di(p-tolyl)benzamidine
• CAS NO: 13471-34-6
• Molecular Weight: 300.403
• Mol File: 13471-34-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N¹,N²-di(p-tolyl)benzamidine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹,N²-di(p-tolyl)benzamidine(13471-34-6)
• EPA Substance Registry System: N¹,N²-di(p-tolyl)benzamidine(13471-34-6)

Safety Data

• Hazardous Substances Data: 13471-34-6(Hazardous Substances Data)

Upstream product

• 1613-92-9 (E)-N-benzylidene-4-toluidine 
• 24251-12-5 tertiary amyl hypochlorite 
• 5720-05-8 4-methylphenylboronic acid 
• 618-39-3 benzamidin 
• 60566-08-7 N,N'-bis(4-methylphenyl)-N-benzoylbenzamidine 
• 13471-16-4 ClB{N(C₆H₄CH₃)(C((NC₆H₄CH₃))C₆H₅)}2 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 100-47-0 benzonitrile 
• 540-23-8 p-toluidine hydrochloride 
• 624-31-7 4-tolyl iodide 
• 106-49-0 p-toluidine 
• 65-85-0 benzoic acid 

Downstream Products

• 112277-35-7 N-(1,2,3,4,5-pentamethoxycarbonylcyclopentadienyl)-N,N'-di(p-tolyl)benzamidine 
• 106210-30-4 bis-(N,N'-di-p-tolylbenzamidino)palladium(II) 
• 90527-04-1 (Re(CO)4(CH₃C₆H₄NHC(C₆H₅)NC₆H₄CH₃)Br) 
• 89173-04-6 Re(CO)3(CH₃C₆H₄NC(C₆H₄)NHC₆H₄CH₃)(CH₃C₆H₄NC(C₆H₅)NHC₆H₄CH₃) 
• 90527-09-6 (Re(CO)4(CH₃C₆H₄NHC(C₆H₅)NC₆H₄CH₃)Cl) 
• 90523-11-8 (Re(CO)4(CON(C₆H₄CH₃)C(C₆H₅)NC₆H₄CH₃)) 
• 112187-09-4 bis(di-p-tolylbenzamidine)platinum(II) 
• 60566-25-8 N-(2,4-Dinitro-phenyl)-N,N'-di-p-tolyl-benzamidine 

Relevant articles and documents

Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a Chan-Lam-Evans N-arylation and C-H activation/C-N bond forming process

Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc) 2 and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct C-H bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 C, afforded benzimidazoles 3 in good to excellent yields.

Efficient access to polysubstituted amidines, benzimidazoles and pyrimidines from amides

Polysubstituted amidines, benzimidazoles and pyrimidines were synthesized via the electrophilic activation of amides with trifluoromethanesulfonic anhydride and 2-chloropyridine. The one-pot protocol is concise and efficient and the substrates are readily available.

A NOVEL DIRECT SYNTHESIS OF AMIDINES FROM CARBOXYLIC ACIDS AND AMINES USING POLYPHOSPHORIC ACID TRIMETHYLSILYL ESTER (PPSE) AS CONDENSING AGENT

It was found that amidines were obtained directly by the reaction of carboxylic acids with amines in the presence of PPSE, and the yields of amidines were dependent on the structure of amines rather than that of carboxylic acids.