13471-34-6

Upstream product

• 624-31-7 4-tolyl iodide 
• 618-39-3 benzamidin 
• 1613-92-9 (E)-N-benzylidene-4-toluidine 
• 24251-12-5 tertiary amyl hypochlorite 
• 540-23-8 p-toluidine hydrochloride 
• 100-47-0 benzonitrile 
• 13471-16-4 ClB{N(C₆H₄CH₃)(C((NC₆H₄CH₃))C₆H₅)}2 
• 60566-08-7 N,N'-bis(4-methylphenyl)-N-benzoylbenzamidine 
• 5720-05-8 4-methylphenylboronic acid 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 106-49-0 p-toluidine 
• 65-85-0 benzoic acid 

Downstream Products

• 91363-36-9 N,N'-Di-p-tolyl-N-(2,4,6-tris-trifluoromethanesulfonyl-phenyl)-benzamidine 
• 60566-25-8 N-(2,4-Dinitro-phenyl)-N,N'-di-p-tolyl-benzamidine 
• 119507-79-8 N,N'-di-p-tolyl-N-(3,5-di-tert-butyl-4-hydroxybenzoyl)benzamidine 
• 112277-35-7 N-(1,2,3,4,5-pentamethoxycarbonylcyclopentadienyl)-N,N'-di(p-tolyl)benzamidine 
• 112187-09-4 bis(di-p-tolylbenzamidine)platinum(II) 
• 90523-11-8 (Re(CO)4(CON(C₆H₄CH₃)C(C₆H₅)NC₆H₄CH₃)) 
• 90527-09-6 (Re(CO)4(CH₃C₆H₄NHC(C₆H₅)NC₆H₄CH₃)Cl) 
• 89173-04-6 Re(CO)3(CH₃C₆H₄NC(C₆H₄)NHC₆H₄CH₃)(CH₃C₆H₄NC(C₆H₅)NHC₆H₄CH₃) 
• 90527-04-1 (Re(CO)4(CH₃C₆H₄NHC(C₆H₅)NC₆H₄CH₃)Br) 
• 106210-30-4 bis-(N,N'-di-p-tolylbenzamidino)palladium(II) 

Relevant academic research and scientific papers

Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a Chan-Lam-Evans N-arylation and C-H activation/C-N bond forming process

Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc) 2 and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct C-H bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 C, afforded benzimidazoles 3 in good to excellent yields.

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

Efficient access to polysubstituted amidines, benzimidazoles and pyrimidines from amides

Polysubstituted amidines, benzimidazoles and pyrimidines were synthesized via the electrophilic activation of amides with trifluoromethanesulfonic anhydride and 2-chloropyridine. The one-pot protocol is concise and efficient and the substrates are readily available.

Organometallic complexes of aluminium, gallium and indium

Novel organometallic complexes of aluminium, gallium and indium are disclosed, having improved stability and volatility for use in CVD processes. These are donor ligand complexes of the formula MR2 L where M is the metal, R is an alkyl group and L is a ligand containing an amidine (R'N. . . C(R'). . . NR') group, where R' is H, alkyl etc.

A NOVEL DIRECT SYNTHESIS OF AMIDINES FROM CARBOXYLIC ACIDS AND AMINES USING POLYPHOSPHORIC ACID TRIMETHYLSILYL ESTER (PPSE) AS CONDENSING AGENT

It was found that amidines were obtained directly by the reaction of carboxylic acids with amines in the presence of PPSE, and the yields of amidines were dependent on the structure of amines rather than that of carboxylic acids.