13471-68-6Relevant articles and documents
Catalysis by palladium salts XIII. The reductive carbonylation of nitroaromatic compounds to isocyanates with PdII and Pd0 complexes as homogeneous catalysts
Ugo, R.,Psaro, R.,Pizzotti, M.,Nardi, P.,Dossi, C.,et.al.
, p. 211 - 233 (1991)
A study has been made of the reductive carbonylation of 2,4-dinitrotoluene (2,4-DNT) to 2,4-diisocyanotoluene (2,4-TDI) with catalysis either by , in the presence of FeO3 and MoO3 or of Fe(MoO4)3 as cocatalysts, or by Pd0 complexes without cocatalysts.In the case of catalytic systems based upon the reaction can be carried out at about 200 deg C and under 200 atm of CO to produce 2,4-TDI with high conversions and acceptable selectivities.With Pd0 complexes as catalysts good conversions can be achieved at much lower temperatures (100-120 deg C) but with a low selectivity when a higher pressure of CO is used (300 atm or more).An investigation of the reductive cabonylation of nitrobenzene to phenylisocyanate as a model system, together with a study of the thermal stability of in the presence of CO, has provided evidence that the actual active catalyst could be a reduced (probably zerovalent) form of palladium stabilised by the nitroaromatic substrate or by some of the products formed from it as ligands.
MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE
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Paragraph 0781; 0782; 0793, (2017/09/20)
Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
Development of N-4,6-pyrimidine-N-alkyl-N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase
Maier, Jennifer A.,Brugel, Todd A.,Sabat, Mark,Golebiowski, Adam,Laufersweiler, Matthew J.,VanRens, John C.,Hopkins, Corey R.,De, Biswanath,Hsieh, Lily C.,Brown, Kimberly K.,Easwaran, Vijayasurian,Janusz, Michael J.
, p. 3646 - 3650 (2007/10/03)
A new class of lymphocyte specific tyrosine kinase (lck) inhibitors based on an N-4,6-pyrimidine-N-alkyl-N′-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar inhibition of lck kinase activity as well as IL-2 synthesis from Ju
