13474-22-1Relevant articles and documents
STEREOSELECTIVE PREPARATION OF β-AMINO-ACYL IRON COMPLEXES FOR β-LACTAM SYNTHESIS
Broadley, Karen,Davies, Stephen G.
, p. 1743 - 1744 (1984)
The enolate derived from 5-C5H5)Fe(PPh3)(CO)(COCH3)> and n-butyl lithium reacts stereoselectively with imines to yield β-amino-acyl complexes which on oxidation give β-lactams.
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Gilman,Speeter
, p. 2255 (1943)
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β-Lactam Formation by Ultrasound-promoted Reformatsky Type Reaction
Bose, Ajay K.,Gupta, Kavita,Manhas, M. S.
, p. 86 - 87 (1984)
Ultrasound was found to promote the reaction between ethyl bromoacetate, zinc, and a Schiff base such that an excellent yield of β-lactams was obtained in a few hours at room temperature.
Copper-Catalyzed Oxidative Benzylic C(sp3)?H Cyclization for the Synthesis of β-Lactams
Nozawa-Kumada, Kanako,Saga, Satoshi,Matsuzawa, Yuta,Hayashi, Masahito,Shigeno, Masanori,Kondo, Yoshinori
, p. 4496 - 4499 (2020/04/10)
β-Lactams are important structural motifs because of their ubiquity in natural products and pharmaceuticals. We report herein a Cu-catalyzed intramolecular oxidative C(sp3)?H amidation for the synthesis of β-lactams using tBuOOtBu. This method
Synthesis of Exclusively 4-Substituted β-Lactams through the Kinugasa Reaction Utilizing Calcium Carbide
Hosseini, Abolfazl,Schreiner, Peter R.
supporting information, p. 3746 - 3749 (2019/05/24)
A new Kinugasa reaction protocol has been elaborated for the one-pot synthesis of 4-substituted β-lactams utilizing calcium carbide and nitrone derivatives. Calcium carbide is thereby activated by TBAF·3H2O in the presence of CuCl/NMI. The ease of synthesis and use of inexpensive chemicals provides rapid access of practical quantities of β-lactams exclusively substituted at position 4.