6846-55-5

Upstream product

• 1117-96-0 Diazoethan 
• 15463-91-9 3-bromo-3-phenylpropionic acid 
• 62-53-3 aniline 
• 64-17-5 ethanol 
• 124-38-9 carbon dioxide 
• 55552-57-3 C₁₄H₁₄BrHgN 
• 105-36-2 ethyl bromoacetate 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 53256-22-7 ethyl β-anilinocinnamate 
• 141-78-6 ethyl acetate 
• 538-51-2 benzylidene phenylamine 
• 100-52-7 benzaldehyde 
• 3768-55-6 N-trimethylsilylaniline 

Downstream Products

• 138646-76-1 ethyl (RS)-3-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}-3-phenylpropionate 
• 1258724-06-9 N-phenyl-N-(1-phenylpent-3-yn-1-yl)pentanamide 
• 1258723-87-3 5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate 
• 738-30-7 1-anilino-1-phenyl-heptan-3-one 
• 62740-72-1 N-phenyl-(1-phenylpentyl)amine 
• 6049-56-5 N-Phenyl-β-phenyl-β-alanine 
• 13474-22-1 1,4-diphenyl-azetidin-2-one 

Relevant academic research and scientific papers

A Ball-Milling-Enabled Reformatsky Reaction

An operationally simple one-jar one-step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre-activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source.

One-Pot Silyl Ketene Acetal-Formation Mukaiyama-Mannich Additions to Imines Mediated by Trimethylsilyl Trifluoromethanesulfonate

In the presence of trimethylsilyl trifluoromethanesulfonate and trialkylamine base, thioesters are readily converted into silyl ketene acetals in situ and undergo Mukaiyama-Mannich addition to N-phenylimines in one pot. The silyl triflate appears to play

Synthesis of N-phenyl β-amino acids via iridium-catalyzed asymmetric hydrogenation using mixed monodentate ligands

The iridium-catalyzed asymmetric hydrogenation of N-phenyl-β- dehydroamino acid derivatives was examined using monodentate phosphoramidite ligands. The highest yields and enantioselectivities were obtained using a mixed ligand approach with PipPhos L1 and

Stereodefined homopropargyl amines by tandem nucleophilic addition/fragmentation of dihydropyridone triflates

Dihydropyridone (DHPD) triflates undergo nucleophile-triggered fragmentation to provide homopropargyl amine derivatives, the stereochemistry of which is defined by starting from readily available β-amino esters.

Hydrogenation of β-N-substituted and β-N,N-disubstituted enamino esters in the presence of iridium(I) catalyst

Several new β-amino esters were prepared in two simple steps from β-keto ester derivatives and primary and secondary amines under mild conditions. The hydrogenation of various enamino esters was performed at 50°C in the presence of iridium catalysts. The new β-N-substituted amino esters were isolated in high yields. Georg Thieme Verlag Stuttgart.

Solvent-free synthesis of β-hydroxy esters and β-amino esters by indium-mediated reformatsky reaction

In a convenient and efficient procedure for the solvent-free synthesis of β-hydroxy esters and β-amino esters, various aldehydes and aldimines undergo a Reformatsky reaction mediated by non-activated indium at room temperature to give the corresponding esters in good to excellent yields. Georg Thieme Verlag Stuttgart.

Natural phosphate modified with lithium nitrate: A new efficient catalyst for the construction of carbon-carbon, carbon-sulfur, and carbon-nitrogen bonds

The addition of small amounts of lithium nitrate to natural phosphate followed by calcination gives a new catalyst Li/NP (weight ratio LiNO3/NP = 1/15). This material showed catalytic activity in the Michael addition of amines, mercaptans, and active methylene compounds to chalcone derivatives with high yields under mild reaction conditions. Li/NP is used as the catalyst for a facile synthesis of -amino acids, -sulfur acids, and 4 H-chromenes under heterogeneous conditions. The usual, undesirable byproducts from the Michael condensation such as 1,2-addition, bis-addition, and polymerization compounds are not observed with this method. The work-up procedure is simplified by simple filtration with the use of Li/NP.

Synthesis of β-lactams and β-aminoesters via high intensity ultrasound-promoted Reformatsky reactions

Reformatsky reactions of an imine, an α-bromoester, zinc dust and a catalytic amount of iodine in dioxane under high intensity ultrasound (HIU) irradiation from an ultrasonic probe are explored. A series of 16 aldimines with varying electronic demands is

The synthesis of β-lactams via a one-pot Reformatsky reaction of imines promoted by Zn/Cp2TiCl2 (cat.)

In the presence of Zn/Cp2TiCl2 (cat.) α-bromoacetates, γ-bromocrotonates or α-bromomethylacrylates react with imines in one-pot to form β-lactams, 3-vinyl-β-lactams or α-methylene-γ-lactams, respectively, at room temperature without

Selective synthesis of β-amino esters and β-lactams by rhodium-catalyzed reformatsky-type reaction

β-Amino esters and β-lactams are synthesized selectively from aldimines and ethyl bromoacetate by applying a simply modified rhodium-catalyzed Reformatsky-type reaction.