1347750-20-2

Basic information

• Product Name: Thiol-PEG5-Amine
• Synonyms: Thiol-PEG5-Amine;HS-PEG5-CH2CH2NH2;HS-PEG5-CH2CH2NH2·HCl;Thiol-PEG5-amine HCl salt
• CAS NO: 1347750-20-2
• Molecular Formula: C12H27NO5S
• Molecular Weight: 297.41148
• Mol File: 1347750-20-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiol-PEG5-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: Thiol-PEG5-Amine(1347750-20-2)
• EPA Substance Registry System: Thiol-PEG5-Amine(1347750-20-2)

Safety Data

• Hazardous Substances Data: 1347750-20-2(Hazardous Substances Data)

Usage

General Description

Thiol-PEG5-Amine is a chemical compound that consists of a thiol group, a polyethylene glycol (PEG) chain with five repeating units, and an amine group. The thiol group provides the compound with reactive properties, allowing it to participate in thiol-ene or thiol-disulfide reactions. The PEG chain provides the compound with solubility and biocompatibility, making it suitable for use in biological and medical applications. The amine group also contributes to the compound's reactivity and can be used for linking the compound to other molecules or surfaces. Thiol-PEG5-Amine is often used in the modification of surfaces, the conjugation of biomolecules, and the preparation of drug delivery systems.

Upstream product

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Relevant articles and documents

NANOPARTICLE-BASED THERAPY OF INFLAMMATORY DISORDERS

The present invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: (i) at least one dilution ligand comprising a carbohydrate, glutathione or a polyethyleneglycol moiety; and (ii) a ligand of the formula MTX-L-, wherein MTX-L-represents methotrexate coupled to said core via a linker L. Also provided are pharmaceutical compositions of the nanoparticle, including gel formulations, and medical uses of the nanoparticle and pharmaceutical compositions, including for the treatment of an inflammatory or autoimmune disorder, such as psoriasis.

NANOPARTICLES AND THEIR USE IN CANCER THERAPY

The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.

NANOPARTICLE PEPTIDE COMPOSITIONS

The present invention relates to amylin peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of blood glucose regulation. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise glutathione; and at least one amylin peptide that is non-covalently bound to the corona.