906007-10-1

Basic information

• Product Name: Azide-PEG6-Tos
• Synonyms: Azide-PEG6-Tos
• CAS NO: 906007-10-1
• Molecular Formula: C₁₉H₃₁N₃O₈S
• Molecular Weight: 461.52974
• Mol File: 906007-10-1.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Azide-PEG6-Tos(CAS DataBase Reference)
• NIST Chemistry Reference: Azide-PEG6-Tos(906007-10-1)
• EPA Substance Registry System: Azide-PEG6-Tos(906007-10-1)

Safety Data

• Hazardous Substances Data: 906007-10-1(Hazardous Substances Data)

Usage

Description

Azide-PEG6-Tos consist of an azide group and a tosyl group. 6 PEG units increases solubility in aqueous media. The azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions.

Upstream product

• 42749-27-9 hexa(ethyleneglycol) ditosylate 
• 42749-28-0 toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester 
• 2615-15-8 pentaethylene glycol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 5197-62-6 2-[2-(chloroethoxy)ethoxy]ethanol 
• 86770-69-6 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol 

Downstream Products

• 906007-17-8 1-azido-17-(4'-hydroxymethyl-2'-methoxy-5'-nitrophenoxy)-3,6,9,12,15-pentaoxaheptadecane 
• 1309456-99-2 C₂₅H₃₆F₄N₄O₁₁S 
• 1402411-90-8 17-azido-1-bromo-3,6,9,12,15-pentaoxaheptadecane 
• 1347750-20-2 1-amino-17-mercapto-3, 6,9,12,15,-pentaoxa-heptadecanol 
• 1233234-77-9 37-amino-5, 8,11,14,17,20,23,26,29,32,35-undecaoxa-2-azaheptatriacontanoic acid tert-butyl ester 
• 1821464-56-5 35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl 4-methylbenzenesulfonate 
• 1293397-04-2 C₃₃H₄₁BrN₆O₉ 
• 1293397-11-1 C₃₄H₄₃BrN₆O₁₀ 

Relevant articles and documents

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

NOVEL BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.