134790-39-9

Basic information

• Product Name: 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
• Synonyms: 2',2'-difluoro-2'-deoxycytidine-3',5'-dibenzoate;Cytidine, 2'-deoxy-2',2'-difluoro-, 3',5'-dibenzoate;2'-Deoxy-3',5'-di-O-benzoyl-2',2'-difluorocytidine, >=97%;T9 of Gemcitabine;2-DEOXY-2,2-DIFLUORO-35-BIS-O-BENZOYLEYTIDINE MONOHYDROCHLORIDE;2’,2’-Difluoro-2’-deoxycyodine-3’,5’-dibenzoate;2'-deoxy-2,2'-difluoro-3,5-dibenzyl-cytidine;2',2'-Difluoro-2'-deoxycyodine-3',5'–dibenzoate ( or its salt) 2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoates-cytidine (or its salt)
• CAS NO: 134790-39-9
• Molecular Formula: C₂₃H₁₉F₂N₃O₆
• Molecular Weight: 471.41
• EINECS: 1806241-263-5
• Product Categories: API intermediates;Amines;Bases & Related Reagents;Heterocycles;Nucleotides
• Mol File: 134790-39-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 229-232°C
• Boiling Point: 608.383 °C at 760 mmHg
• Flash Point: 321.739 °C
• Appearance: Tan solid
• Density: 1.459 g/cm³
• Storage Temp.: Refrigerator
• Solubility: DMSO
• PKA: 4.26±0.10(Predicted)
• CAS DataBase Reference: 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate(134790-39-9)
• EPA Substance Registry System: 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate(134790-39-9)

Safety Data

• Hazardous Substances Data: 134790-39-9(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

Different sources of media describe the Uses of 134790-39-9 differently. You can refer to the following data:
1. A (-anomer) intermediate of Gemcitabine; antitumor compound
2. A (β-anomer) intermediate of Gemcitabine; antitumor compound.

Synthetic route

3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose (134877-42-2, 134877-43-3, 122111-11-9) + 2,4-O,N-bis(trimethylsilyl)cytosine (18037-10-0) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
In toluene at 120℃; for 6h; Temperature;	97.38%

4-Amino-1-trimethylsilanyl-1H-pyrimidin-2-one (73416-12-3) + 2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate (134877-42-2) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
With phosphomolybdic acid In pentan-1-ol at 70 - 137℃; for 5h; Reagent/catalyst; Solvent; Temperature; Reflux;	95%

2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate (134877-42-2) + 2,4-O,N-bis(trimethylsilyl)cytosine (18037-10-0) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
at 120℃; for 3h; Heating;	85.5%

3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose (134877-42-2, 134877-43-3, 122111-11-9) + 2,4-O,N-bis(trimethylsilyl)cytosine (18037-10-0) → C23H19F2N3O6 (134790-40-2) + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;

(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate (1173824-58-2) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 2: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 5 - 20 °C 2: 3 h / 120 °C / Heating View Scheme

2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate (122111-01-7) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme

Cytosine (71-30-7) + 2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate (134877-42-2) → C23H19F2N3O6 (134790-40-2) + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
With potassium sulfate; lithium chloride at 120 - 125℃; for 4h; Overall yield = 85.7 %; Overall yield = 405.2 g;	A n/a B n/a

3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose (134877-42-2, 134877-43-3, 122111-11-9) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / 50 - 60 °C 2: 3 h / 120 °C / Heating View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C23H20F2N2O7

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; acetic acid In water; ethyl acetate at 50 - 60℃; under 3750.38 Torr; for 18h;	95.6%
Stage #1: (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate With hydrogenchloride In water; ethyl acetate for 0.0833333h; Stage #2: With formic acid; 5%-palladium/activated carbon In water; ethyl acetate at 68 - 70℃; for 24h; Inert atmosphere;

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → gemcitabine (95058-81-4)

Conditions	Yield
With ammonium hydroxide In methanol at 20℃; for 3h;	82.7%
With sodium t-butanolate In methanol at 20℃; for 2h;

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → Benzoic acid (2R,3R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4,4-difluoro-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Conditions	Yield
With ammonia In methanol

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C34H55F2N3O8

Conditions	Yield
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → 2',2'-difluoro-2'-deoxycytidine 3',5'-di-n-decanoate

Conditions	Yield
Multi-step reaction with 4 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C30H37F2N3O6Si

Conditions	Yield
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: dmap / N,N-dimethyl-formamide / 20 °C View Scheme
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: N,N-lutidine / N,N-dimethyl-formamide / 20 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → tert-butyl [1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamate

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C View Scheme

di-tert-butyl dicarbonate (24424-99-5) + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C28H27F2N3O8

Conditions	Yield
With dmap; triethylamine In 1,4-dioxane at 40℃; for 5h;
With N,N-lutidine In 1,4-dioxane at 40℃; for 5h;

3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose (134877-42-2, 134877-43-3, 122111-11-9) + 2,4-O,N-bis(trimethylsilyl)cytosine (18037-10-0) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
In toluene at 120℃; for 6h; Temperature;	97.38%

4-Amino-1-trimethylsilanyl-1H-pyrimidin-2-one (73416-12-3) + 2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate (134877-42-2) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
With phosphomolybdic acid In pentan-1-ol at 70 - 137℃; for 5h; Reagent/catalyst; Solvent; Temperature; Reflux;	95%

2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate (134877-42-2) + 2,4-O,N-bis(trimethylsilyl)cytosine (18037-10-0) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
at 120℃; for 3h; Heating;	85.5%

3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose (134877-42-2, 134877-43-3, 122111-11-9) + 2,4-O,N-bis(trimethylsilyl)cytosine (18037-10-0) → C23H19F2N3O6 (134790-40-2) + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;

(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate (1173824-58-2) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 2: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 5 - 20 °C 2: 3 h / 120 °C / Heating View Scheme

2-deoxy-2,2-difluoro-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate (122111-01-7) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme

Cytosine (71-30-7) + 2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate (134877-42-2) → C23H19F2N3O6 (134790-40-2) + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
With potassium sulfate; lithium chloride at 120 - 125℃; for 4h; Overall yield = 85.7 %; Overall yield = 405.2 g;	A n/a B n/a

3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose (134877-42-2, 134877-43-3, 122111-11-9) → (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / 50 - 60 °C 2: 3 h / 120 °C / Heating View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C23H20F2N2O7

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; acetic acid In water; ethyl acetate at 50 - 60℃; under 3750.38 Torr; for 18h;	95.6%
Stage #1: (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate With hydrogenchloride In water; ethyl acetate for 0.0833333h; Stage #2: With formic acid; 5%-palladium/activated carbon In water; ethyl acetate at 68 - 70℃; for 24h; Inert atmosphere;

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → gemcitabine (95058-81-4)

Conditions	Yield
With ammonium hydroxide In methanol at 20℃; for 3h;	82.7%
With sodium t-butanolate In methanol at 20℃; for 2h;

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → Benzoic acid (2R,3R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4,4-difluoro-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Conditions	Yield
With ammonia In methanol

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C23H22F2N2O7

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / ethyl acetate; water / 0.08 h 1.2: 24 h / 68 - 70 °C / Inert atmosphere 2.1: cerium(III) chloride heptahydrate / dichloromethane; ethanol / 0.08 h 2.2: 2 h / 0 - 6 °C View Scheme
Multi-step reaction with 2 steps 1: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 18 h / 50 - 60 °C / 3750.38 Torr 2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / water; dichloromethane; ethanol / 2 h / 6 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → 2’-deoxy-2’,2’-difluorotetrahydrouridine (1141397-48-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: hydrogenchloride / ethyl acetate; water / 0.08 h 1.2: 24 h / 68 - 70 °C / Inert atmosphere 2.1: cerium(III) chloride heptahydrate / dichloromethane; ethanol / 0.08 h 2.2: 2 h / 0 - 6 °C 3.1: ammonia / methanol / 27 h / 25 °C View Scheme
Multi-step reaction with 3 steps 1: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 18 h / 50 - 60 °C / 3750.38 Torr 2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / water; dichloromethane; ethanol / 2 h / 6 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol / 3 h / 40 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → (4R)-2’-deoxy-2’,2’-difluoro-3,4,5,6-tetrahydrouridine (1141397-80-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: hydrogenchloride / ethyl acetate; water / 0.08 h 1.2: 24 h / 68 - 70 °C / Inert atmosphere 2.1: cerium(III) chloride heptahydrate / dichloromethane; ethanol / 0.08 h 2.2: 2 h / 0 - 6 °C 3.1: ammonia / methanol / 27 h / 25 °C 4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / water; acetonitrile / 74 h / 25 °C / Large scale 4.2: 16 h / 0 - 40 °C / Large scale View Scheme
Multi-step reaction with 4 steps 1: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 18 h / 50 - 60 °C / 3750.38 Torr 2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / water; dichloromethane; ethanol / 2 h / 6 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol / 3 h / 40 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / water; acetonitrile / 48 h / 20 - 30 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C9H9F2N3O6P(1-)*Na(1+)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: ammonium hydroxide / methanol / 3 h / 20 °C 2.1: pyridine; trichlorophosphate / 0 - 20 °C 2.2: 0.5 h / pH 3 - 4 3.1: sodium hydrogencarbonate / ethanol; water / 3 h View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → 1-[(4aR,6R,7aR)-7,7-difluoro-2-hydroxy-2-oxo-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]-4-amino-pyrimidin-2-one

Conditions	Yield
Multi-step reaction with 2 steps 1.1: ammonium hydroxide / methanol / 3 h / 20 °C 2.1: pyridine; trichlorophosphate / 0 - 20 °C 2.2: 0.5 h / pH 3 - 4 View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C34H55F2N3O8

Conditions	Yield
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → 2',2'-difluoro-2'-deoxycytidine 3',5'-di-n-decanoate

Conditions	Yield
Multi-step reaction with 4 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C30H37F2N3O6Si

Conditions	Yield
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: dmap / N,N-dimethyl-formamide / 20 °C View Scheme
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: N,N-lutidine / N,N-dimethyl-formamide / 20 °C View Scheme

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → tert-butyl [1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamate

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C View Scheme

di-tert-butyl dicarbonate (24424-99-5) + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C28H27F2N3O8

Conditions	Yield
With dmap; triethylamine In 1,4-dioxane at 40℃; for 5h;
With N,N-lutidine In 1,4-dioxane at 40℃; for 5h;

n-decyl chloroformate (55488-51-2) + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → C34H39F2N3O8

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1.5h;

Reaxys ID: 37235391 + (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate (134790-39-9) → Reaxys ID: 37235389

Upstream product

• 134877-42-2 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose 
• 18037-10-0 2,4-O,N-bis(trimethylsilyl)cytosine 
• 134877-42-2 2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate 
• 71-30-7 Cytosine 
• 73416-12-3 4-Amino-1-trimethylsilanyl-1H-pyrimidin-2-one 
• 122111-01-7 2-deoxy-2,2-difluoro-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate 
• 1173824-58-2 (2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate 

Downstream Products

• 95058-81-4 gemcitabine 

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