134816-23-2

Basic information

• Product Name: methyl N-((benzyloxy)carbonyl)-N-methyl-L-valyl-L-prolinate
• Synonyms: methyl N-((benzyloxy)carbonyl)-N-methyl-L-valyl-L-prolinate
• CAS NO: 134816-23-2
• Molecular Weight: 376.453
• Mol File: 134816-23-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl N-((benzyloxy)carbonyl)-N-methyl-L-valyl-L-prolinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-((benzyloxy)carbonyl)-N-methyl-L-valyl-L-prolinate(134816-23-2)
• EPA Substance Registry System: methyl N-((benzyloxy)carbonyl)-N-methyl-L-valyl-L-prolinate(134816-23-2)

Safety Data

• Hazardous Substances Data: 134816-23-2(Hazardous Substances Data)

Upstream product

• 42417-65-2 Z-MeVal-OH 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 501-53-1 benzyl chloroformate 
• 845293-30-3 methyl N-(tert-butoxycarbonyl)-N-methyl-L-valyl-L-prolinate 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 

Downstream Products

• 134816-24-3 Z-(S)-Val-NMe-(S)-Val-(S)-Pro-OCH₃ 
• 123884-00-4 dolastatin 15 
• 160811-54-1 Z-(S)-Val-NMe-(S)-Val-(S)-Pro 
• 160811-56-3 (S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 160811-55-2 Z-(S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 123884-00-4 (-)-dolastatin 15 

Relevant articles and documents

MALT1 INHIBITORS AND USES THEREOF

Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

The Dolastatins 20. Convenient Synthetic Route to Dolastatin 15

A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15.Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c -> 3