160811-55-2

Upstream product

• 182573-17-7 NMe-(S)-Val-(S)-Pro-OMe 
• 134816-22-1 (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl] ester 1-tert-butyl ester 
• 134816-24-3 Z-(S)-Val-NMe-(S)-Val-(S)-Pro-OCH₃ 
• 134816-20-9 (5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 134816-23-2 methyl N-((benzyloxy)carbonyl)-N-methyl-L-valyl-L-prolinate 
• 142350-56-9 (S)-5-Benzyl-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryl]-4-hydroxy-1,5-dihydro-pyrrol-2-one 
• 134816-26-5 O-t-butyldimethylsilyl-(S)-Hiva-(S)-Phe-OMe 
• 134816-27-6 N-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-L-phenylalanine 
• 134816-21-0 (5S)-1-((2S)-2-hydroxy-isovaleryl)-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 134816-19-6 (S)-Hiva-(S)-Phe-OMe 
• 160811-53-0 (S)-Pyrrolidine-2-carboxylic acid (S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl ester 
• 160811-54-1 Z-(S)-Val-NMe-(S)-Val-(S)-Pro 
• 42417-65-2 Z-MeVal-OH 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 

Downstream Products

• 123884-00-4 dolastatin 15 
• 160811-56-3 (S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 

Relevant academic research and scientific papers

The Dolastatins 20. Convenient Synthetic Route to Dolastatin 15

A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15.Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c -> 3