123884-00-4

Basic information

• Product Name: DOLASTATIN 15
• Synonyms: DOLASTATIN 15;(5S)-1-[(2S)-O-(N,N-DIMETHYL-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE;(5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE;(5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one;L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-;L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-;Nsc 617668;(5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
• CAS NO: 123884-00-4
• Molecular Formula: C₄₅H₆₈N₆O₉
• Molecular Weight: 837.06
• Mol File: 123884-00-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 943.2°Cat760mmHg
• Flash Point: 524.2°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: −20°C
• CAS DataBase Reference: DOLASTATIN 15(CAS DataBase Reference)
• NIST Chemistry Reference: DOLASTATIN 15(123884-00-4)
• EPA Substance Registry System: DOLASTATIN 15(123884-00-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 123884-00-4(Hazardous Substances Data)

Usage

Uses

Dolastatin 15 is an apoptotic agent through Blc-2 phosphorylation.

InChI:InChI=1/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53)/t31-,32-,33-,36-,37-,38-,39-/m0/s1

Upstream product

• 182573-16-6 (S)-N-[(S)-1-Benzyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-2-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyramide 
• 111657-62-6 H-Pro-ProOtBu * HCl 
• 962-39-0 L-Phenylalanine benzyl ester 
• 160811-55-2 Z-(S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 160811-54-1 Z-(S)-Val-NMe-(S)-Val-(S)-Pro 
• 160811-53-0 (S)-Pyrrolidine-2-carboxylic acid (S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl ester 
• 182573-17-7 NMe-(S)-Val-(S)-Pro-OMe 
• 134816-24-3 Z-(S)-Val-NMe-(S)-Val-(S)-Pro-OCH₃ 
• 134816-23-2 methyl N-((benzyloxy)carbonyl)-N-methyl-L-valyl-L-prolinate 
• 142350-56-9 (S)-5-Benzyl-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryl]-4-hydroxy-1,5-dihydro-pyrrol-2-one 
• 134816-26-5 O-t-butyldimethylsilyl-(S)-Hiva-(S)-Phe-OMe 
• 134816-27-6 N-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-L-phenylalanine 
• 134816-19-6 (S)-Hiva-(S)-Phe-OMe 
• 42417-65-2 Z-MeVal-OH 

Related news

Synthesis and in vitro cytotoxicity of diastereoisomerically modified DOLASTATIN 15 (cas 123884-00-4) analogues08/21/2019

Dolastatin 15 1(4S,7S) is a potent cytostatic depsipeptide of marine origin. Analysis of the effects of the stereochemistry in the non-peptide moiety on activity revealed that chirality inversion in the aromatic terminal region preserves the antiproliferative activity.detailed

Synthesis of DOLASTATIN 15 (cas 123884-00-4) mimetic peptoids08/19/2019

Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.detailed

Relevant articles and documents

Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid

Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull

Total Synthesis of the Proposed Structure of Dolastatin 15

Efficient synthesis of dolastatin 15 (1) was accomplished following a convergent strategy.The pyrrolidinone cycle of 5 was obtained by thermic cyclization of the corresponding Meldrum's adduct 4.The methylation of the enol function was performed under Mit