123884-00-4

Usage

Uses

Dolastatin 15 is an apoptotic agent through Blc-2 phosphorylation.

InChI:InChI=1/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53)/t31-,32-,33-,36-,37-,38-,39-/m0/s1

Upstream product

• 42417-65-2 Z-MeVal-OH 
• 2812-32-0 N,N-dimethyl-L-valine 
• 160811-56-3 (S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 962-39-0 L-Phenylalanine benzyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 142370-94-3 tert-butyl -L-valyl-(N-methyl-L-valyl)-L-prolyl-L-prolinate 
• 142350-64-9 Val-MeVal-Pro-ProOtBu*HCl 
• 142350-62-7 (S)-1-[(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid 
• 142350-58-1 tert-butyl -(N-methyl-L-valyl)-L-prolyl-L-prolinate 
• 142350-63-8 H-MeVal-Pro-ProOtBu * HCl 
• 142350-57-0 tert-butyl -L-prolyl-L-prolinate 
• 182573-16-6 (S)-N-[(S)-1-Benzyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-2-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyramide 
• 111657-62-6 H-Pro-ProOtBu * HCl 
• 51871-50-2 (S)-benzyl 2-((S)-2-(tert-butoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 

Related news

Synthesis and in vitro cytotoxicity of diastereoisomerically modified DOLASTATIN 15 (cas 123884-00-4) analogues08/21/2019

Dolastatin 15 1(4S,7S) is a potent cytostatic depsipeptide of marine origin. Analysis of the effects of the stereochemistry in the non-peptide moiety on activity revealed that chirality inversion in the aromatic terminal region preserves the antiproliferative activity.detailed

Synthesis of DOLASTATIN 15 (cas 123884-00-4) mimetic peptoids08/19/2019

Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.detailed

Relevant academic research and scientific papers

Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid

Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull

The Dolastatins 20. Convenient Synthetic Route to Dolastatin 15

A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15.Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c -> 3

Total Synthesis of the Proposed Structure of Dolastatin 15

Efficient synthesis of dolastatin 15 (1) was accomplished following a convergent strategy.The pyrrolidinone cycle of 5 was obtained by thermic cyclization of the corresponding Meldrum's adduct 4.The methylation of the enol function was performed under Mit