134857-33-3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 100-47-0 benzonitrile 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 95482-67-0 4-(dimethylamino)-4-(ethoxycarbonyl)-5,6-bis(methoxycarbonyl)-2-phenyl-4H-1,3-thiazine 
• 103112-01-2 N-glycine ethyl ester 
• 102254-73-9 Dimethylamino-[(E)-thiobenzoylimino]-acetic acid ethyl ester 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Synthesis of Pyrrole Derivatives Using Thioimidates

Dimethyl acetylenedicarboxylate, ethyl propiolate, nitro olefins, or 2-nitroalkyl acetates react with thioimidate in the presence of organic bases to give the corresponding pyrroles in moderate-to-good yields.

Application of the Cu(i)/TEMPO/O2 catalytic system for aerobic oxidative dehydrogenative aromatization of pyrrolidines

A Cu(i)/TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy)-catalyzed aerobic oxidative dehydrogenative aromatization reaction of fully saturated pyrrolidines to synthesize multi-substituted pyrroles was developed for the first time. The use of a non-precious metal catalyst, green oxidant and environmentally friendly solvent made the reaction more sustainable.

Formation of Acyl-Substituted Nitrile Ylides by Rh2(OAc)4-Catalyzed Decomposition of α-Diazocarbonyl Compounds in Nitriles

The Rh2(OAc)4-catalyzed reactions of α-diazocarbonyl compounds in nitrile in the presence of dimethyl acetylenedicarboxylate (DMAD) gave oxazole and pyrrole derivatives.The formation of the oxazole derivatives is explained in terms of the 1,5-cyclization of an acyl-substituted nitrile ylide intermediate, and the formation of the pyrrole derivatives is explained by the 1,3-dipolar cycloaddition of the same intermediate with DMAD.The regiochemistry of the cycloaddition of the acyl-substituted nitrile ylide with methyl propiolate showed that the contribution of an allenyl-type resonance structure plays an important role in the acyl-substituted nitrile ylide reaction.

Reduction electrochimique de 4H-1,3-thiazines : obtention de 6H-1,3-thiazines et (ou) de pyrroles substitues

Controlled potential electroreduction (protic medium, mercury cathode) of substituted 2-ethoxy and 2-phenyl-4H-1,3-thiazines leads to 6H-1,3-thiazines and (or) pyrroles.The nature of the isolated products appears strongly dependent on pH of the medium and

Formation and Reaction of Acyl Substituted Nitrile Ylide through the Rh2(OAc)4-Catalyzed Reaction of α-Diazocarbonyl Compounds with Benzonitrile

The rhodium(II) acetate-catalyzed reaction of α-diazocarbonyl compounds with benzonitrile and dimethyl acetylenedicarboxylate gave oxazoles and pyrrole-3,4-dicarboxylates through the 1,5-cyclization and 1,3-dipolar cycloaddition of the acyl substituted nitrile ylide intermediates generated by the reaction of ketocarbenoids with benzonitrile.

A selective electrochemical way to functionalized 6H-1,3-thiazines and/or pyrroles

4H-1,3-thiazines, easily prepared from 1-thia-3-azabutadienes, appear electroactive in protic medium. Controlled potential electroreductions of 4H-1,3-thiazines lead either to substituted 6H-1,3-thiazines or to pyrroles according to the nature of the C-4