134872-23-4Relevant articles and documents
In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)- 5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor
Li, Jin,Lynch, Michael P.,DeMello, Kristin Lundy,Sakya, Subas M.,Cheng, Hengmiao,Rafka, Robert J.,Bronk, Brian S.,Jaynes, Burton H.,Kilroy, Carolyn,Mann, Donald W.,Haven, Michelle L.,Kolosko, Nicole L.,Petras, Carol,Seibel, Scott B.,Lund, Lisa A.
, p. 1805 - 1809 (2005)
The synthesis of a novel canine COX-2 selective inhibitor, 2-(3-difluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, and its in vitro and in vivo profile are described. Pyrazole 8 demonstrated excellent potency and selectivity for canine COX-2
PCSK9 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 184-185, (2020/07/31)
The invention relates to a novel inhibitor pharmacophore of PCSK9 and heteroaryl compounds that bind the PCSK9 protein.
NOVEL COMPOUNDS AS GPR119 AGONISTS
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Paragraph 0607-0609, (2017/10/26)
The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation thereof.