134875-74-4

Upstream product

• 4829-02-1 (S)-(+)-2-hydroxy-2-phenylcyclohexanone 
• 591-51-5 phenyllithium 
• 4829-02-1 2-hydroxy-2-phenylcyclohexanone 
• 100-58-3 phenylmagnesium bromide 
• 51128-50-8 2-[(trimethylsilyl)oxy]cyclohex-2-en-1-one 
• 765-87-7 cyclohexane-1,2-dione 
• 10316-66-2 2-hydroxy-2-cyclohexen-1-one 
• 4912-59-8 (1R,2R)-1-phenyl-1,2-cyclohexanediol 
• 23313-43-1 cis-acetic acid 2-hydroxy-2-phenyl-cyclohexyl ester 
• 4912-59-8 1-phenyl-1,2-cyclohexanediol 

Downstream Products

• 3375-38-0 1,4-dibenzoylbutane 
• 72930-73-5 cis-1,2-Diphenylcyclohexane-1,2-diol 

Relevant academic research and scientific papers

Geometric requirements in the ferriin oxidation of benzylic 1,2-diols

The rates of ferriin [i.e. tris(1,10-phenanthroline)iron(III)] oxidation of cis- and trans-1,2-diphenylcyclohexane-1,2-diol have been found to be dramatically different; cis-1,2-diphenylcyclohexane-1,2-diol reacts a minimum of 104 times faster than the corresponding trans-isomer; implications for the oxidation of benzylic diols by ferriin are discussed.

Oxidative Cleavage of vic-Diols Using Copper(II) Bromide-Lithium t-Butoxide: A New Route to Unsymmetrical 1,5- and 1,6-Diketones

Unsymmetrical 1,6-diketones were obtained by the copper(II) bromide-lithium t-butoxide oxidation of 1,2-disubstituted 1,2-cyclohexanediols. The diols were easily prepared by the addition of Grignard reagents to 2-trimethylsiloxy-2-cyelohexenone followed by the hydrolysis and treatment of the resulting 2-hydroxycyclohexanones with the second Grignard reagents. Similarly, 1,5-Diketones were obtained using 2-trimethylsiloxy-2-cyclopentenone as a starting material.

Preparation and Enantiomer Recognition Behaviour of Crown Ethers containing cis-1-Phenylcyclohexane-1,2-diol and trans-1,2-Diphenylcyclohexane-1,2-diol as a Chiral Subunit

Pig liver esterase-mediated hydrolysis of (+/-)-cis-2-acetoxy-1-phenylcyclohexanol 5 gave (+)-cis-1-phenylcyclohexane-1,2-diol 4 of high optical purity, from which (-)-trans-1,2-diphenylcyclohexane-1,2-diol 8 has been prepared.Using these diols (+)-4 and

Synthesis and Enantiomer Recognition of Crown Ethers containing Cyclohexane-1,2-diol Derivatives as the Chiral Centre and Enzymatic Resolution of the Chiral Subunits

The cyclohexane-1,2-diol derivatives 1 and 4 of high optical purity have been prepared by enantioselective hydrolysis of their acetates (+/-)-2 and (+/-)-5 using pig liver esterase.The enantiomer recognition behaviour of the chiral crown ethers 11, 14, 15