13497-85-3

Usage

Uses

Used in Medical Applications:
Cobinamide is used as an antidote for cyanide poisoning due to its ability to rapidly and effectively neutralize cyanide toxicity. It binds with cyanide ions to form a stable complex, detoxifying the body and preventing the harmful effects of cyanide exposure.
Used in Emergency Medicine:
In the field of emergency medicine, Cobinamide is being investigated as a potential antidote for treating patients who have been exposed to cyanide, a highly toxic substance that can cause rapid and severe health complications. The development of Cobinamide as an antidote could significantly improve the treatment options and outcomes for cyanide-poisoned patients.
Used in Toxicology Research:
Cobinamide's unique properties and potential as a cyanide antidote make it a valuable subject of research in toxicology. Studies on Cobinamide's mechanism of action, efficacy, and safety are crucial for understanding its potential applications in treating cyanide poisoning and developing new antidotes for this life-threatening condition.
Used in Pharmaceutical Development:
The ongoing research into the clinical efficacy and safety of Cobinamide as a treatment for cyanide poisoning is aimed at developing a new antidote for pharmaceutical use. If proven effective and safe, Cobinamide could become an essential component of medical countermeasures against cyanide exposure, providing a life-saving treatment option for affected individuals.

InChI:InChI=1/C48H73N11O8.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;/h19,23,26-29,43,60H,10-18,20-22H2,1-9H3,(H14,49,50,51,52,53,54,55,56,57,58,59,61,62,63,64,65,66,67);/q;+2/p-1/t23-,26-,27-,28-,29+,43-,45-,46+,47+,48+;/m1./s1

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cobinamide (cas 13497-85-3) chemistries for photometric cyanide determination. A merging zone liquid core waveguide cyanide analyzer using cyanoaquacobinamide (cas 13497-85-3)08/16/2019

Diaquacobinamide (H2O)2Cbi2+ or its conjugate base hydroxyaquacobinamide (OH(H2O)Cbi+)) can bind up to two cyanide ions, making dicyanocobinamide. This transition is accompanied by a significant change in color, previously exploited for cyanide determination. The reagent OH(H2O)Cbi+ is used in e...detailed

Simultaneous determination of 3-mercaptopyruvate and cobinamide (cas 13497-85-3) in plasma by liquid chromatography–tandem mass spectrometry08/15/2019

The current suite of Food and Drug Administration (FDA) approved antidotes (i.e., sodium nitrite, sodium thiosulfate, and hydroxocobalamin) are effective for treating cyanide poisoning, but individually, each antidote has major limitations (e.g., large effective dosage or delayed onset of action...detailed

Intramuscular cobinamide (cas 13497-85-3) Sulfite in a Rabbit Model of Sublethal Cyanide Toxicity08/14/2019

Study objectiveExposure to cyanide in fires and industrial exposures and intentional cyanide poisoning by terrorists leading to mass casualties is an ongoing threat. Current treatments for cyanide poisoning must be administered intravenously, and no rapid treatment methods are available for mass...detailed

Intravenous cobinamide (cas 13497-85-3) Versus Hydroxocobalamin for Acute Treatment of Severe Cyanide Poisoning in a Swine (Sus scrofa) Model08/13/2019

Study objectiveHydroxocobalamin is a Food and Drug Administration–approved antidote for cyanide poisoning. Cobinamide is a potential antidote that contains 2 cyanide-binding sites. To our knowledge, no study has directly compared hydroxocobalamin with cobinamide in a severe, cyanide-toxic large...detailed

High performance liquid chromatography tandem mass spectrometry assay for the determination of cobinamide (cas 13497-85-3) in pig plasma08/11/2019

Liquid chromatography-tandem mass spectrometry (LC–MS/MS) has been widely utilized for the analysis of compounds in biological matrices due to its selectivity and sensitivity. This study describes the application of an LC–MS/MS-based approach toward the analysis of cobinamide in Yorkshire pig ...detailed

Comparative study of reaction of cobalamin and cobinamide (cas 13497-85-3) with thiocyanate08/10/2019

The interaction of Co(III) and Co(II) cobalamin (Cbl) and cobinamide (Cbi) with thiocyanate was examined with UV–vis and EPR spectra. S/N-linkage isomerism was explored on Co(III) and Co(II) Cbl and Cbi models using density functional theory (DFT; BP86, B3LYP). Performed calculations suggest th...detailed

Mechanistic basis of vitamin B12 and cobinamide (cas 13497-85-3) salvaging by the Vibrio species08/08/2019

Biosynthesis of vitamin B12, which occurs through salvaging pathway or de novo synthesis, is essential for the survival and growth of bacteria. While the mechanism is known for many bacteria, it is elusive yet for diarrhea causing pathogenic bacteria Vibrio cholerae or the other Vibrio species. ...detailed