Intravenous cobinamide (cas 13497-85-3) Versus Hydroxocobalamin for Acute Treatment of Severe Cyanide Poisoning in a Swine (Sus scrofa) Model

Add time:08/13/2019    Source:sciencedirect.com

Study objectiveHydroxocobalamin is a Food and Drug Administration–approved antidote for cyanide poisoning. cobinamide (cas 13497-85-3) is a potential antidote that contains 2 cyanide-binding sites. To our knowledge, no study has directly compared hydroxocobalamin with cobinamide in a severe, cyanide-toxic large-animal model. Our objective is to compare the time to return of spontaneous breathing in swine with acute cyanide-induced apnea treated with intravenous hydroxocobalamin, intravenous cobinamide, or saline solution (control).

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