1349839-16-2Relevant academic research and scientific papers
A one-pot efficient four-component reaction for the synthesis of 2-(arylamino)-2-(5-aryl-1,3,4-oxadiazol-2-yl)propyl benzoate (or acetate) derivatives
Ramazani, Ali,Ahmadi, Yavar,Malekzadeh, Asemeh Mashhadi,Rezaei, Aram
experimental part, p. 692 - 698 (2012/01/03)
Reactions of (N-isocyanimino) triphenylphosphorane with 2-oxopropylbenzoate (or acetate) in the presence of aromatic carboxylic acids and primary amines proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions were observed.
