134984-77-3

Basic information

• Product Name: ethyl trans-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate
• Synonyms: ethyl trans-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate
• CAS NO: 134984-77-3
• Molecular Weight: 275.391
• Mol File: 134984-77-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl trans-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl trans-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate(134984-77-3)
• EPA Substance Registry System: ethyl trans-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate(134984-77-3)

Safety Data

• Hazardous Substances Data: 134984-77-3(Hazardous Substances Data)

Upstream product

• 78-79-5 isoprene 
• 37662-06-9 ethyl <(S)-1-phenylethyl>iminoethanoate 
• 37662-05-8 ((R)-1-phenyl-ethylimino)-acetic acid ethyl ester 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 134984-61-5 (6S)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine 
• 139334-62-6 (6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine 

Downstream Products

• 74892-82-3 ethyl (2R-trans)-4-methylpiperidine-2-carboxylate 
• 79199-61-4 ethyl 4-methylpipeloate 
• 78306-52-2 ethyl (2S,4S)-4-methylpiperidine-2-carboxylate 

Relevant articles and documents

Enantio- and Diastereo-selective Synthesis of Pipecolic Acid Derivatives using the Aza-Diels-Alder Reaction of Imines with Dienes

Optically active pipecolic acid derivatives can be prepared by the aza-Diels-Alder reaction of simple dienes with the imine derived from ethyl glyoxylate and chiral 1-phenylethylamine; the cycloadditions are regiospecific, highly diastereoselective within the heterocyclic ring (>92percent exo with cyclic dienes, and 100percent endo with acyclic dienes), and lead to high asymmetric induction in most cases (average d.e. = 72percent).