1349854-28-9 Usage
General Description
The chemical (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid ethyl ester, also known as dexketoprofen, is an enantiomer of ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID). It is commonly used for its analgesic and anti-inflammatory properties and is often prescribed to manage acute and chronic pain, such as that associated with rheumatoid arthritis, osteoarthritis, and other musculoskeletal conditions. Dexketoprofen works by inhibiting the production of prostaglandins, which are involved in the body's inflammatory response. It is typically administered orally or topically and can provide rapid and effective pain relief with a lower risk of gastrointestinal side effects compared to other NSAIDs. However, as with all medications, it is important to use dexketoprofen under the guidance of a healthcare professional to minimize potential risks and maximize its benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 1349854-28-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,9,8,5 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1349854-28:
(9*1)+(8*3)+(7*4)+(6*9)+(5*8)+(4*5)+(3*4)+(2*2)+(1*8)=199
199 % 10 = 9
So 1349854-28-9 is a valid CAS Registry Number.
1349854-28-9Relevant articles and documents
Enantioselective epoxidation by the chiral auxiliary approach: Asymmetric total synthesis of (+)-Ambrisentan
Madhu, Madasu,Doda, Sai Reddy,Begari, Prem Kumar,Dasari, Krishna Rao,Thalari, Gangadhar,Kadari, Sudhakar,Yadav, Jhillu Singh
, p. 942 - 946 (2021)
Enantioselective and a highly concise total synthesis of Ambrisentan are described. The chiral auxiliary controlled enantioselective epoxidation (Azerad protocol), photochemical regioselective epoxide opening, and base mediated ester hydrolysis reactions
Synthesis of (+)-ambrisentan via chiral ketone-catalyzed asymmetric epoxidation
Peng, Xianyou,Li, Peijun,Shi, Yian
experimental part, p. 701 - 703 (2012/03/26)
The synthesis of optically pure (+)-ambrisentan has been achieved from 3,3-diphenylacrylate in four steps with 53% overall yield and >99% ee at the >100 g scale without column purification. The chiral epoxide intermediate was prepared via asymmetric epoxi
