1349854-31-4Relevant articles and documents
Synthesis of (+)-ambrisentan via chiral ketone-catalyzed asymmetric epoxidation
Peng, Xianyou,Li, Peijun,Shi, Yian
, p. 701 - 703 (2012)
The synthesis of optically pure (+)-ambrisentan has been achieved from 3,3-diphenylacrylate in four steps with 53% overall yield and >99% ee at the >100 g scale without column purification. The chiral epoxide intermediate was prepared via asymmetric epoxi
Method for Preparing Optically Pure (+)-Ambrisentan and (+)-Darusentan
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, (2014/09/16)
Disclosed is a method for preparing optically pure (+)-ambrisentan and (+)-darusentan, comprising: firstly catalyzing the asymmetric epoxidation of a β-unsaturated alkene using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to an epoxy compound ring-opening reaction and substitution reaction successively to obtain optically pure (+)-ambrisentan and (+)-darusentan.
