135033-55-5

Upstream product

• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 135033-58-8 (S)-1-Phenyl-1-(3R,7aS)-tetrahydro-pyrrolo[1,2-c]oxazol-3-yl-pentan-1-ol 
• 135033-59-9 (S)-Cyclohexyl-phenyl-(3R,7aS)-tetrahydro-pyrrolo[1,2-c]oxazol-3-yl-methanol 
• 135033-59-9 (R)-Cyclohexyl-phenyl-(3R,7aS)-tetrahydro-pyrrolo[1,2-c]oxazol-3-yl-methanol 
• 102473-43-8 Toluene-4-sulfonic acid (R)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester 
• 102473-43-8 Toluene-4-sulfonic acid (S)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester 
• 20585-37-9 (R)-(-)-2-Cyclohexyl-2-hydroxy-2-phenyl-acetaldehyd 
• 20585-32-4 (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylacetaldehyde 
• 149597-98-8 (R)-(-)-1-cyclohexyl-1-phenyl-1,3-propanediol 
• 114499-81-9 (S)-(+)-1-cyclohexyl-1-phenyl-1,3-propanediol 
• 149714-31-8 (R)-(-)-1-cyclohexyl-1-phenyl-2-propen-1-ol 
• 135033-61-3 (S)-(+)-1-cyclohexyl-1-phenyl-2-propen-1-ol 
• 40520-25-0 (-)-Trihexyphenidyl 
• 40520-24-9 (+)-Trihexyphenidyl 
• 69489-14-1 (S)-(+)-2-hydroxy-2-phenylpropanal 

Relevant academic research and scientific papers

Stereodivergent synthesis of optically active tertiary alcohols via addition reaction of chiral 2-acyl oxazolidine with organometallics

It was observed that diastereoselectivity in an addition reaction to chiral 2-acyl oxazolidine, derived from (S)-prolinol, can be fully regulated under appropriate conditions. Addition of organotitanium triisopropoxides provided (S)-tertiary alcohols, while organolithium reagents afforded the corresponding (R)-alcohols. Application of this methodology was demonstrated in the synthesis of (+)- and (-)-trihexyphenidyl.