135033-59-9

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 135033-55-5 (2R)-Benzoyl-3-oxa-1-azabicyclo<3.3.0>octane 
• 931-50-0 cyclohexylmagnesium bromide 
• 10074-42-7 cyclohexyllithium 

Downstream Products

• 102473-43-8 Toluene-4-sulfonic acid (R)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester 
• 149597-98-8 (R)-(-)-1-cyclohexyl-1-phenyl-1,3-propanediol 
• 149714-31-8 (R)-(-)-1-cyclohexyl-1-phenyl-2-propen-1-ol 
• 40520-25-0 (-)-Trihexyphenidyl 
• 20585-37-9 (R)-(-)-2-Cyclohexyl-2-hydroxy-2-phenyl-acetaldehyd 
• 102473-43-8 Toluene-4-sulfonic acid (S)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester 
• 114499-81-9 (S)-(+)-1-cyclohexyl-1-phenyl-1,3-propanediol 
• 135033-61-3 (S)-(+)-1-cyclohexyl-1-phenyl-2-propen-1-ol 
• 40520-24-9 (+)-Trihexyphenidyl 
• 20585-32-4 (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylacetaldehyde 

Relevant academic research and scientific papers

Stereodivergent synthesis of optically active tertiary alcohols via addition reaction of chiral 2-acyl oxazolidine with organometallics

It was observed that diastereoselectivity in an addition reaction to chiral 2-acyl oxazolidine, derived from (S)-prolinol, can be fully regulated under appropriate conditions. Addition of organotitanium triisopropoxides provided (S)-tertiary alcohols, while organolithium reagents afforded the corresponding (R)-alcohols. Application of this methodology was demonstrated in the synthesis of (+)- and (-)-trihexyphenidyl.