135033-61-3Relevant academic research and scientific papers
Anticholinergic Agents 3. Synthesis and Configurational Assignment of the Four Stereoisomers of 1-Cyclohexyl-1,2-epoxy-1-phenyl-3-piperidinylpropane
Sjoe, Peter,Aasen, Arne Joergen
, p. 486 - 491 (2007/10/02)
The four stereoisomers of 1-cyclohexyl-1,2-epoxy-1-phenyl-3-piperidylpropane which are putative muscarinic antagonists, have been synthesised employing (S)- and (R)-1-cyclohexyl-1-phenyl-1,3-propanediol as chiral synthons.The relative configuration of the
Stereodivergent synthesis of optically active tertiary alcohols via addition reaction of chiral 2-acyl oxazolidine with organometallics
Ukaji, Yutaka,Yamamoto, Kouji,Fukui, Masashi,Fujisawa, Tamotsu
, p. 2919 - 2922 (2007/10/02)
It was observed that diastereoselectivity in an addition reaction to chiral 2-acyl oxazolidine, derived from (S)-prolinol, can be fully regulated under appropriate conditions. Addition of organotitanium triisopropoxides provided (S)-tertiary alcohols, while organolithium reagents afforded the corresponding (R)-alcohols. Application of this methodology was demonstrated in the synthesis of (+)- and (-)-trihexyphenidyl.
