135040-86-7Relevant academic research and scientific papers
Facile preparation of 2-arylbenzo[b]furan molecules and their anti-inflammatory effects
Hwang, Jung Woon,Choi, Da Hye,Jeon, Jae-Ho,Kim, Jin-Kyung,Jun, Jong-Gab
experimental part, p. 965 - 970 (2010/11/02)
An efficient and practical preparation of 2-arylbenzo[b]furan molecules including natural egonol, XH-14, ailanthoidol, and unnatural derivatives is demonstrated using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared benzo[b]furans were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that ailanthoidol, XH-14 and three other unnatural derivatives (9-10, 13) inhibited significantly the production of inflammatory mediator nitric oxide without showing cytotoxicity.
Regioselective Introduction of Carbon-3 Substituents to 5-Alkyl-7-methoxy-2-phenylbenzofurans: Synthesis of a Novel Adenosine A1 Receptor Ligand and Its Derivatives
Yang, Zhen,Liu, Han Biao,Lee, Chi Ming,Chang, Hson Mou,Wong, Henry N. C.
, p. 7248 - 7257 (2007/10/02)
By maintaining the balance between the electronic requirements, the stereochemical restrictions as well as the kinetic and thermodynamic factors, the unprecedented regioselective electrophilic aromatic substitution of formyl and nitro groups to carbon-3 o
Naturally Occurring Benzofuran: Isolation, Structure Elucidation and Total Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde, a Novel Adenosine A1 Receptor Ligand Isolated from Salvia miltior
Yang, Zhen,Hon, Po Ming,Chui, Kuk Ying,Xu, Zun Le,Chang, Hson Mou,et al.
, p. 2061 - 2064 (2007/10/02)
A naturally occurring benzofuran, namely 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde was isolated from the roots of S. miltiorrhiza Bunge "Danshen".Its structure was established by means of spectroscopic metho
