144735-57-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropal is used as a therapeutic agent for its potential anti-inflammatory and antioxidant properties. Its ability to modulate inflammatory pathways and scavenge free radicals makes it a promising candidate for the treatment of various inflammatory and oxidative stress-related disorders.
Used in Anticancer Applications:
In the field of oncology, 2-(4-Hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropal is used as an anticancer agent. Its potential to target cancer cells and inhibit their growth and proliferation has been demonstrated in various studies. It may be employed in combination with conventional chemotherapy to enhance the therapeutic effects and overcome drug resistance in cancer treatment.
Used in Antimicrobial Applications:
2-(4-Hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropal is used as an antimicrobial agent due to its ability to inhibit the growth of various microorganisms, including bacteria and fungi. Its potential use in the development of new antibiotics and antifungal agents can help address the growing issue of antibiotic resistance and the need for novel antimicrobial therapies.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic efficacy of 2-(4-Hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropal, various drug delivery systems have been explored. These systems, including nanoparticles and liposomes, aim to improve the compound's solubility, stability, and targeted delivery to specific tissues or cells, thereby optimizing its pharmacological effects and minimizing side effects.

Upstream product

• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 61222-88-6 methyl 3-methoxy-4-hydroxy-5-bromocinnamate 
• 144735-53-5 β-(3-methoxy-4-(benzyloxy)phenyl)-β-chloracrolein 
• 515814-05-8 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran 
• 1486-52-8 3-methoxy-4-benzyloxybenzoyl chloride 
• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 213970-70-8 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran 
• 135040-86-7 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-(benzyloxy)phenyl)benzofuran 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 144735-54-6 1-ethynyl-4-(benzyloxy)-3-methoxybenzene 
• 144735-55-7 5-(2-(methoxycarbonyl)trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-(benzyloxy)phenyl)benzofuran 
• 121-33-5 vanillin 
• 1835-11-6 4-benzyloxy-3-methoxyacetophenone 
• 144735-56-8 5-((2-methoxycarbonyl)ethyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 

Downstream Products

• 144735-69-3 4-acetyl-5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 
• 144735-76-2 3-cyano-5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 
• 70610-22-9 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan 
• 144735-70-6 3-acetyl-5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 
• 135040-89-0 5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-4-carbaldehyde 
• 135040-90-3 5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde 
• 135040-88-9 2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxybenzofuran 
• 135040-83-4 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde 
• 36307-23-0 5-(3-hydroxypropyl)-7-methoxy-3-methyl-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 
• 144735-68-2 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran 
• 144735-77-3 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-4-carbaldehyde 

Relevant academic research and scientific papers

An alternate method for the synthesis of 2-aryl/alkyl-5-bromo-7-methoxy benzofurans; application to the synthesis of Egonol, Homoegonol, and analogs via Heck reaction

We herein report the general, versatile, and convenient method for the synthesis of 2-arly/alkyl-5-bromo-7-methoxy benzofurans from easily available o-Vanillin in five steps. These benzofurans was successfully converted into biological active natural products Egonol, Homoegonol, and analogous on applying Heck reaction using ethyl/methyl acrylate in the presence of palladium catalyst.

NOVEL 2-PHENYLBENZOFURAN DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASE COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same

Facile preparation of 2-arylbenzo[b]furan molecules and their anti-inflammatory effects

An efficient and practical preparation of 2-arylbenzo[b]furan molecules including natural egonol, XH-14, ailanthoidol, and unnatural derivatives is demonstrated using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared benzo[b]furans were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that ailanthoidol, XH-14 and three other unnatural derivatives (9-10, 13) inhibited significantly the production of inflammatory mediator nitric oxide without showing cytotoxicity.

Regioselective Introduction of Carbon-3 Substituents to 5-Alkyl-7-methoxy-2-phenylbenzofurans: Synthesis of a Novel Adenosine A1 Receptor Ligand and Its Derivatives

By maintaining the balance between the electronic requirements, the stereochemical restrictions as well as the kinetic and thermodynamic factors, the unprecedented regioselective electrophilic aromatic substitution of formyl and nitro groups to carbon-3 o