1350469-22-5

Upstream product

• 89-51-0 Homophthalic acid 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 256397-61-2 6-methyl-4'-trifluoromethyl-1,1'-biphenyl-2-carboxylic acid 
• 256397-64-5 [6-METHYL-4'-(TRIFLUOROMETHYL)-[1, 1'-BIPHENYL]-2-CARBONYL] 
• 1350469-24-7 ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 480451-75-0 5-chloro-N,N-dimethyl-2-nitrobenzamide 
• 14961-34-3 diethyl homophthalate 
• 79016-11-8 ethyl 2-(1-bromo-2-ethoxy-2-oxoethyl)benzoate 
• 1350468-51-7 (+/-)-ethyl 2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350468-52-8 (+/-)-ethyl 1-(hydroxymethyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350469-23-6 ethyl (1R)-1-({2-[3-(dimethylcarbamoyl)-4-nitrophenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350469-50-9 diethyl 2-(3-(dimethylcarbamoyl)-4-(6-methyl-4′-(trifluoromethyl)-[1,1′-biphenyl]-2-carboxamido)phenyl)malonate 
• 1350468-50-6 ethyl (R)-1-(hydroxymethyl)-2-methyl-3-oxoisoindoline-1-carboxylate 
• 1350469-51-0 2-(3-(dimethylcarbamoyl)-4-(6-methyl-4′-(trifluoromethyl)-[1,1′-biphenyl]-2-carboxamido)phenyl)acetic acid 

Relevant academic research and scientific papers

Utilization of ReactIR in fit for purpose process enablement

An efficient four-step synthesis of 1 is described in which utilization of ReactIR was key to efficient processing and reaction monitoring. Key chemical steps included (i) nucleophilic aromatic substitution, iron reduction of aromatic nitro group to anili

2-PHENYL BENZOYLAMIDES

Compounds of Formula I that inhibit microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion and their uses in the treatment of diseases linked thereto in animals are described herein.