150438-02-1

Basic information

• Product Name: 1H-Imidazole-5-carboxylicacid,2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[2-(2,2,2-trifluoroacetyl)-1H-pyrrol-1-yl]-
• Synonyms: 1H-Imidazole-5-carboxylicacid,2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-(9CI); CI 996
• CAS NO: 150438-02-1
• Molecular Formula: C27H22 F3 N7 O3
• Molecular Weight: 549.512
• Mol File: 150438-02-1.mol

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-5-carboxylicacid,2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[2-(2,2,2-trifluoroacetyl)-1H-pyrrol-1-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-5-carboxylicacid,2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[2-(2,2,2-trifluoroacetyl)-1H-pyrrol-1-yl]-(150438-02-1)
• EPA Substance Registry System: 1H-Imidazole-5-carboxylicacid,2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[2-(2,2,2-trifluoroacetyl)-1H-pyrrol-1-yl]-(150438-02-1)

Safety Data

• Hazardous Substances Data: 150438-02-1(Hazardous Substances Data)

Upstream product

• 150437-98-2 methyl 2-propyl-5-<2-(trifluoroacetyl)-1H-pyrrol-1-yl>-1H-imidazole-4-carboxylate 
• 150437-91-5 2-Propyl-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid methyl ester 
• 150437-97-1 methyl 2-propyl-4-(1H-pyrrol-1-yl)-1H-imidazole-5-carboxylate 
• 150437-96-0 methyl 4-amino-2-propyl-1H-imidazole-5-carboxylate 
• 150437-95-9 methyl N-(N'-cyanobutyrimidoyl)glycinate 
• 1711-02-0 4-iodobenzoic acid chloride 
• 1026262-77-0 2-Propyl-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 143722-28-5 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole 
• 157756-27-9 5-<4'-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl><1,1'-biphenyl>-2-yl>-2-(triphenylmethyl)-1H-tetrazole 
• 135050-95-2 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol 
• 147283-96-3 4-(tert-butyldimethylsiloxymethyl)iodobenzene 
• 15290-29-6 4-(trimethylsilyl)benzoic acid 
• 6999-03-7 1-bromo-4-(trimethylsilyl)benzene 
• 18282-51-4 4-iodo-benzyl alcohol 

Relevant articles and documents

Model reactions targeted at the synthesis of carbon-14 labeled CI-996, a potent antagonist of angiotensin II receptor (1)

A reaction sequence suitable for the preparation of an analog of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-4-[2-(tr ifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid, with 14C at the methylene bridge was developed. The would-be labeled fragment (12) was derived from 4-iodobenzenemethanol (6) which itself was constructed from 1,4-dibromobenzene by the application of silicon chemistry. Pd(o) catalyzed coupling of TBDMS protected 6 and a tetrazole borate 10 gave the compound 12 which upon further transformation to the mesylate 13, N-alkylated an imidazole to furnish target compound.

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: Profile of 2-propyl-1-[[2'-(tetrazol-5-yl)-[1,1'-biphenyl]-4- yl]-methyl]-4-[2-(trifluoroace

A novel series of nonpeptide angiotensin II (AII) receptor antagonists containing a 1H-pyrrol-1-yl moiety at the 4-position of the imidazole have been developed. The pyrrole group occupies the same lipophilic pocket at the receptor as the chloro group in