135053-20-2

Basic information

• Product Name: CIS-1-AMINO-INDAN-2-CARBOXYLIC ACID
• Synonyms: CIS-1-AMINO-INDAN-2-CARBOXYLIC ACID
• CAS NO: 135053-20-2
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.2
• Mol File: 135053-20-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 363.6°C at 760 mmHg
• Flash Point: 173.7°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 6.34E-06mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: CIS-1-AMINO-INDAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-1-AMINO-INDAN-2-CARBOXYLIC ACID(135053-20-2)
• EPA Substance Registry System: CIS-1-AMINO-INDAN-2-CARBOXYLIC ACID(135053-20-2)

Safety Data

• Hazardous Substances Data: 135053-20-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO2/c11-9-7-4-2-1-3-6(7)5-8(9)10(12)13/h1-4,8-9H,5,11H2,(H,12,13)/t8-,9+/m1/s1

Upstream product

• 95-13-6 1-indene 

Downstream Products

• 55269-97-1 [(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl] methanol 
• 1422851-66-8 N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2R)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide 
• 1422851-31-7 (+)-N¹-(4-chloro-3-fluorophenyl)-N²-(trans-2-(guanidinomethyl)indan-1-yl)oxalamide formate salt 
• 1422851-67-9 N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide 
• 1422851-73-7 N¹-((1R,2R)-2-(azidomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl) oxalamide 
• 1422851-70-4 [(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate 
• 1422851-50-0 N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide 

Relevant articles and documents

Structure-based design and synthesis of an HIV-1 entry inhibitor exploiting X-ray and thermodynamic characterization

The design, synthesis, thermodynamic and crystallographic characterization of a potent, broad spectrum, second-generation HIV-1 entry inhibitor that engages conserved carbonyl hydrogen bonds within gp120 has been achieved. The optimized antagonist exhibits a submicromolar binding affinity (110 nM) and inhibits viral entry of clade B and C viruses (IC50 geometric mean titer of 1.7 and 14.0 μM, respectively), without promoting CD4-independent viral entry. The thermodynamic signatures indicate a binding preference for the (R,R)- over the (S,S)-enantiomer. The crystal structure of the small-molecule/gp120 complex reveals the displacement of crystallographic water and the formation of a hydrogen bond with a backbone carbonyl of the bridging sheet. Thus, structure-based design and synthesis targeting the highly conserved and structurally characterized CD4-gp120 interface is an effective tactic to enhance the neutralization potency of small-molecule HIV-1 entry inhibitors.

Vapour-assisted enzymatic hydrolysis of β-lactams in a solvent-free system

A new, solvent-free, vapour-assisted method, developed for the synthesis of carbocyclic cis β-amino acid enantiomers through the Candida antarctica lipase B-catalysed enantioselective (E >200) hydrolysis of β-lactams with 0.5 equiv of H2O at 70 °C, has been demonstrated to be applicable on a preparative scale to produce (±)-2 (the starting racemate for cispentacin), (±)-3 (the starting racemate for 4-tert-butylcispentacin, a new cispentacin analogue) and (±)-7 (the starting racemate for 1,4-ethylene-bridged cispentacin).