1350621-35-0Relevant articles and documents
Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand
Liu, Feng,Wu, Na,Cheng, Xu
supporting information, p. 3015 - 3020 (2021/05/05)
Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.
One-pot microwave-assisted synthesis and antimalarial activity of ferrocenyl benzodiazepines
Mwande-Maguene, Gabin,Jakhlal, Jouda,Lekana-Douki, Jean-Bernard,Mouray, Elisabeth,Bousquet, Till,Pellegrini, Sylvain,Grellier, Philippe,Ndouo, Fousseyni Samba Toure,Lebibi, Jacques,Pelinski, Lydie
scheme or table, p. 2412 - 2415 (2012/01/04)
An efficient synthesis of 1,4-benzodiazepin-2-ones is described by condensation between 2-aminobenzophenone and Boc-protected amino acids via microwave-assisted irradiation. This produces higher yields in shorter reaction times than with traditional methods. The antiplasmodial activity of the corresponding ferrocenyl benzodiazepines was evaluated in vitro against Plasmodium falciparum F32 (chloroquine-sensitive) and FCB1 and K1 (chloroquine-resistant) strains and gabonese clinical isolates.
