13507-15-8

Basic information

• Product Name: Acetamide, hydrochloride
• CAS NO: 13507-15-8
• Molecular Formula: C2H5NO.ClH
• Molecular Weight: 95.5287
• Mol File: 13507-15-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetamide, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, hydrochloride(13507-15-8)
• EPA Substance Registry System: Acetamide, hydrochloride(13507-15-8)

Safety Data

• Hazardous Substances Data: 13507-15-8(Hazardous Substances Data)

Usage

General Description

Acetamide hydrochloride is a chemical compound with the molecular formula C2H5NO.HCl. It is a white crystalline solid soluble in water and ethanol, and has a melting point of 114-116°C. Acetamide hydrochloride is used as a pharmaceutical intermediate in the synthesis of various drugs, as well as a reagent in organic synthesis. It is also used in the production of aniline, dyes, and pesticides. Additionally, acetamide hydrochloride has been studied for its potential antineoplastic activity, making it a subject of interest in cancer research. However, it is important to handle and use this chemical with caution, as it can irritate the skin, eyes, and respiratory system.

Upstream product

• 60-35-5 acetamide 
• 75-05-8 acetonitrile 

Downstream Products

• 5451-83-2 acetic acid 3-methoxyphenyl ester 
• 122-46-3 3-acetoxytoluene 
• 1205-91-0 benzene-1,4-diyl diacetate 
• 95206-97-6 6-Isopropyl-2-methyl-pyrimidin-4-ylamine 
• 92289-38-8 4-amino-2-methyl-6-phenylpyrimidine 
• 108-78-1 2,4,6-triamino-s-triazine 
• 1193-21-1 4,6-dichloropyrimidine 
• 98021-25-1 5,6-dihydroxy-2-methyl-(3H)-pyrimidin-4-one 
• 533-18-6 2-methylphenyl acetate 

Relevant articles and documents

Efficient transformation of nitrile into amide under mild condition

Transformation of various kinds of nitriles into the corresponding amides or amide salts was performed in good yields by the addition of two equiv of chlorotrimethylsilane and two equiv of water at 0°C to 25°C.

Amide substituted imidazopyridines

Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Certain alpha-substituted arylsulfonamido acetohydroxamic acids

Particularly the invention relates to the compounds of formula I STR1 wherein Ar represents carbocyclic aryl, heterocyclic aryl or biaryl; R1 represents lower alkyl, cycloalkyl, aryl-lower alkyl, lower alkoxy-lower alkyl, aryl, cycloalkyl-lower alkyl, halo-lower alkyl; R2 represents hydrogen or lower alkyl; R3 and R4 represent independently hydrogen, lower alkyl, lower alkoxy, halo, hydroxy, acyloxy, lower alkoxy-lower alkoxy, trifluoromethyl or cyano; or R3 and R4 together represent lower allylenedioxy; n represents an integer from 1 to 5; pharmaceutically acceptable prodrug derivatives; and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting TNF-alpha activity and matrix-degrading metalloproteinases in mammals using such compounds.