1350730-03-8

Basic information

• Product Name: 2,6-difluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile
• Synonyms: 2,6-difluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile
• CAS NO: 1350730-03-8
• Molecular Weight: 409.395
• Mol File: 1350730-03-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-difluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-difluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile(1350730-03-8)
• EPA Substance Registry System: 2,6-difluoro-3-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzonitrile(1350730-03-8)

Safety Data

• Hazardous Substances Data: 1350730-03-8(Hazardous Substances Data)

Upstream product

• 1350660-03-5 4-[3-(2-chloro-pyrimidin-5-yloxy)phenyl]morpholine 
• 143879-78-1 3-amino-2,6-difluoro-benzonitrile 
• 863377-22-4 [3-(morpholine-4-yl)phenyl]boronic acid 
• 197846-82-5 1-(3-bromophenyl)-morpholine 
• 108-36-1 1,3-dibromobenzene 

Relevant articles and documents

COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: wherein R1 is CN; R2 is H or F; R3 and R4 are independently hydrogen, fluorine, chlorine or OR5; R5 is hydrogen, C1-6 alkyl, C1-6 alkenyl or C1-6 alkynyl; R6 and R7 are independently hydrogen, halogen, OR8 or NR9R10; R8 is hydrogen or C1-6 alkyl; R9 and R10 are independently hydrogen or C1-6 alkyl; or the groups R9 and R10 when they are attached to a nitrogen atom may together form a 5- or 6-membered ring which optionally contains one further heteroatom selected from NR8, S and O said 5 or 6 membered ring being optionally substituted by hydroxyl or C1-6 alkoxy; or the groups R9 and R10 when they are attached to a nitrogen atom may together form an azetidinyl ring optionally substituted by hydroxyl or C1-6 alkoxy, is provided. The use of such compounds in treating amyloid-related disease is also disclosed.