151504-80-2

Basic information

• Product Name: 2-CHLORO-4-NITROBENZOTRIFLUORIDE
• Synonyms: 2-CHLORO-4-NITROBENZOTRIFLUORIDE;2-Chloro-4-nitro-1-trifluoromethylbenzene;2-Chloro-4-nitro-1-(trifluoromethyl)benzene, 3-Chloro-4-(trifluoromethyl)nitrobenzene
• CAS NO: 151504-80-2
• Molecular Formula: C₇H₃ClF₃NO₂
• Molecular Weight: 225.55
• Mol File: 151504-80-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 247.4 °C at 760 mmHg
• Flash Point: 103.4 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.511
• Vapor Pressure: 0.0405mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-CHLORO-4-NITROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-NITROBENZOTRIFLUORIDE(151504-80-2)
• EPA Substance Registry System: 2-CHLORO-4-NITROBENZOTRIFLUORIDE(151504-80-2)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 151504-80-2(Hazardous Substances Data)

Usage

General Description

2-CHLORO-4-NITROBENZOTRIFLUORIDE is a chemical compound with the molecular formula C7H3ClF3NO2. It is a yellow solid that is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is a highly reactive compound and is known to be harmful if inhaled, swallowed, or absorbed through the skin. It is also a potential environmental hazard and should be handled with caution.

InChI:InChI=1/C7H3ClF3NO2/c8-6-3-4(12(13)14)1-2-5(6)7(9,10)11/h1-3H

Upstream product

• 121-87-9 2-Chloro-4-nitroaniline 
• 41252-96-4 3-chloro-4-iodonitrobenzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 77152-08-0 trifluoromethylcopper(I) 

Downstream Products

• 1350816-18-0 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione 
• 1350816-61-3 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 1351438-88-4 di-tert-butyl ((Z)-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate 
• 1350816-60-2 3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)aniline 
• 1350816-59-9 N,N-dimethyl-3-[5-nitro-2-(trifluoromethyl)phenyl]prop-2-yn-1-amine 
• 73483-06-4 2,3'-Bis(trifluoromethyl)-4'-chloro-4-nitrodiphenylamine 
• 445-13-6 3-chloro-4-(trifluoromethyl)aniline 
• 94444-58-3 2-chloro-4-fluoro-1-(trifluoromethyl)benzene 

Relevant articles and documents

Conversion of aromatic amino into trifluoromethyl groups through a Sandmeyer-type transformation

A novel strategy for aromatic trifluoromethylation by converting amino into trifluoromethyl groups via a Sandmeyer-type reaction is reported. The transformation involves diazotization of the aromatic amines with tert-butyl nitrite and hydrochloric acid to form aryldiazonium chlorides, followed by trifluoromethylation with trifluoromethylsilver at low temperature. Various readily available aromatic amines are smoothly converted under mild conditions. Georg Thieme Verlag Stuttgart. New York.

ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP

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Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.