151504-80-2

Basic information

• Product Name: 2-CHLORO-4-NITROBENZOTRIFLUORIDE
• Synonyms: 2-CHLORO-4-NITROBENZOTRIFLUORIDE;2-Chloro-4-nitro-1-trifluoromethylbenzene;2-Chloro-4-nitro-1-(trifluoromethyl)benzene, 3-Chloro-4-(trifluoromethyl)nitrobenzene
• CAS NO: 151504-80-2
• Molecular Formula: C₇H₃ClF₃NO₂
• Molecular Weight: 225.55
• Mol File: 151504-80-2.mol

Chemical Properties

• Boiling Point: 247.4 °C at 760 mmHg
• Flash Point: 103.4 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.511
• Vapor Pressure: 0.0405mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-CHLORO-4-NITROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-NITROBENZOTRIFLUORIDE(151504-80-2)
• EPA Substance Registry System: 2-CHLORO-4-NITROBENZOTRIFLUORIDE(151504-80-2)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 151504-80-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-4-NITROBENZOTRIFLUORIDE is used as a synthetic intermediate for the production of various pharmaceuticals. Its reactivity allows for the creation of complex organic molecules that are essential in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-4-NITROBENZOTRIFLUORIDE serves as a key intermediate in the synthesis of pesticides and other crop protection agents. Its role in creating effective and targeted agrochemicals is vital for enhancing crop yields and ensuring food security.
Used in Specialty Chemicals Industry:
2-CHLORO-4-NITROBENZOTRIFLUORIDE is also utilized in the synthesis of specialty chemicals, which are high-value compounds used in specific applications such as dyes, fragrances, and other industrial processes. Its versatility in chemical reactions makes it a valuable component in the production of these specialized products.

InChI:InChI=1/C7H3ClF3NO2/c8-6-3-4(12(13)14)1-2-5(6)7(9,10)11/h1-3H

Upstream product

• 41252-96-4 3-chloro-4-iodonitrobenzene 
• 77152-08-0 trifluoromethylcopper(I) 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 121-87-9 2-Chloro-4-nitroaniline 

Downstream Products

• 94444-58-3 2-chloro-4-fluoro-1-(trifluoromethyl)benzene 
• 445-13-6 3-chloro-4-(trifluoromethyl)aniline 
• 73483-06-4 2,3'-Bis(trifluoromethyl)-4'-chloro-4-nitrodiphenylamine 
• 1350816-59-9 N,N-dimethyl-3-[5-nitro-2-(trifluoromethyl)phenyl]prop-2-yn-1-amine 
• 1350816-60-2 3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)aniline 
• 1351438-88-4 di-tert-butyl ((Z)-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate 
• 1350816-61-3 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 1350816-18-0 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione 

Relevant articles and documents

Conversion of aromatic amino into trifluoromethyl groups through a Sandmeyer-type transformation

A novel strategy for aromatic trifluoromethylation by converting amino into trifluoromethyl groups via a Sandmeyer-type reaction is reported. The transformation involves diazotization of the aromatic amines with tert-butyl nitrite and hydrochloric acid to form aryldiazonium chlorides, followed by trifluoromethylation with trifluoromethylsilver at low temperature. Various readily available aromatic amines are smoothly converted under mild conditions. Georg Thieme Verlag Stuttgart. New York.

Silver-mediated trifluoromethylation of aryldiazonium salts: Conversion of amino group into trifluoromethyl group

A novel strategy for aromatic trifluoromethylation by converting aromatic amino group into CF3 group is reported herein. This method, which can be considered as trifluoromethylation variation of the classic Sandmeyer reaction, uses readily available aromatic amines as starting materials and is performed under mild conditions.

Thiourea inhibitors of herpes viruses. Part 1: Bis-(aryl)thiourea inhibitors of CMV

Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate.

Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

Diaminopuridine-containing thiourea inhibitors of herpes viruses

Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.