1350852-18-4Relevant academic research and scientific papers
Synthesis of 2′-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides
Masaki, Yoshiaki,Yamamoto, Keishi,Inde, Takeshi,Yoshida, Keita,Maruyama, Atsuya,Nagata, Tetsuya,Tanihata, Jun,Takeda, Shin'ichi,Sekine, Mitsuo,Seio, Kohji
, p. 160 - 163 (2019)
The effect of 2′-O-(N-methylcarbamoyl)ethyl (MCE) modification on splice-switching oligonucleotides (SSO) was systematically evaluated. The incorporation of five MCE nucleotides at the 5′-termini of SSOs effectively improved the splice switching effect. I
Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties
Ohkubo, Akihiro,Nishino, Yudai,Yokouchi, Akira,Ito, Yu,Noma, Yasuhiro,Kakishima, Yuuki,Masaki, Yoshiaki,Tsunoda, Hirosuke,Seio, Kohji,Sekine, Mitsuo
supporting information; experimental part, p. 12556 - 12558 (2012/02/03)
In this study, it was found that the arrangement of consecutive thiocarbonyl groups of s2T and m5s2C remarkably stabilized the pre-protonated form of the triplex, and that the stabilization of the pre-protonated form increased the pKa value of a cytosine derivative in the triplex.
