1350888-75-3Relevant academic research and scientific papers
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
Kumar, Nag S.,Amandoron, Emily A.,Cherkasov, Artem,Brett Finlay,Gong, Huansheng,Jackson, Linda,Kaur, Sukhbir,Lian, Tian,Moreau, Anne,Labrière, Christophe,Reiner, Neil E.,See, Raymond H.,Strynadka, Natalie C.,Thorson, Lisa,Wong, Edwin W.Y.,Worrall, Liam,Zoraghi, Roya,Young, Robert N.
, p. 7069 - 7082 (2012)
A novel series of hydrazones were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK has been identified as one of the most highly connected 'hub proteins' in MRSA. PK has been shown to b
ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES, AND METHODS
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Page/Page column 55, (2012/05/05)
Compounds having a structure of Formulas A-C are provided. Uses of such compounds as an antibiotic, including both gram-negative and gram-positive micro-organisms, as well as methods of treatment and uses involving such compounds are provided.
