39635-10-4

Basic information

• Product Name: 5-BROMO-2-HYDROXYBENZOHYDRAZIDE
• Synonyms: 5-BROMO-2-HYDROXYBENZOHYDRAZIDE;5-bromo-2-hydroxybenzohydrazide(SALTDATA: FREE)
• CAS NO: 39635-10-4
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.06
• Mol File: 39635-10-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.756g/cm³
• Refractive Index: 1.656
• CAS DataBase Reference: 5-BROMO-2-HYDROXYBENZOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-HYDROXYBENZOHYDRAZIDE(39635-10-4)
• EPA Substance Registry System: 5-BROMO-2-HYDROXYBENZOHYDRAZIDE(39635-10-4)

Safety Data

• Hazardous Substances Data: 39635-10-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-hydroxybenzohydrazide is a chemical compound with the formula C7H6BrN3O2. It is a white to off-white crystalline solid that is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals. 5-BROMO-2-HYDROXYBENZOHYDRAZIDE has been found to possess antimicrobial and antifungal properties, making it useful in the development of drugs and agrochemicals. Additionally, it has been studied for its potential application in the treatment of neurodegenerative diseases due to its antioxidant properties. Overall, 5-Bromo-2-hydroxybenzohydrazide is a versatile chemical with a range of potential applications in various industries.

InChI:InChI=1/C7H7BrN2O2/c8-4-1-2-6(11)5(3-4)7(12)10-9/h1-3,11H,9H2,(H,10,12)

Upstream product

• 89-55-4 5-bromosalicyclic acid 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 

Downstream Products

• 92439-66-2 piperonal-(5-bromo-2-hydroxy-benzoylhydrazone) 
• 1350888-90-2 (E)-N'-(1-(1H-indol-2-yl)propylidene)-5-bromo-2-hydroxybenzohydrazide 
• 1373438-15-3 (E)-5-bromo-2-hydroxy-N'-(1-(4,5,6-trifluoro-1H-indol-2-yl)ethylidene)benzohydrazide 
• 1373438-12-0 (E)-5-bromo-N'-(1-(7-fluoro-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide 
• 1373438-14-2 (E)-5-bromo-N'-(1-(4,5-difluoro-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide 
• 1350888-86-6 (E)-5-bromo-N'-(1-(5,6-difluoro-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide 
• 1373438-69-7 (E)-5-bromo-N'-(1-(6-bromo-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide 
• 1373438-16-4 (E)-5-bromo-2-hydroxy-N'-(1-(5-phenyl-1H-indol-2-yl)ethylidene)benzohydrazide 
• 1373438-13-1 (E)-5-bromo-2-hydroxy-N'-(1-(5-methoxy-1H-indol-2-yl)ethylidene)benzohydrazide 
• 1373438-70-0 (E)-5-bromo-2-hydroxy-N'-(1-(5-hydroxy-1H-indol-2-yl)ethylidene)benzohydrazide 
• 1373438-75-5 5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide 
• 1373438-60-8 (E)-N'-(1-(benzo[b]thiophen-2-yl)ethylidene)-5-bromo-2-hydroxybenzohydrazide 
• 1373438-32-4 (E)-5-bromo-2-hydroxy-N'-((1-methyl-1H-indol-2-yl)(phenyl)methylene)benzohydrazide 
• 1373438-33-5 C₂₃H₁₈BrN₃O₂ 

Relevant articles and documents

SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clinically relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clinical drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.