13511-84-7

Upstream product

• 833-20-5 o-(2-nitrophenyl)-N,N-dimethylthiocarbamate 
• 824-39-5 sodium o-nitrophenate 
• 88-75-5 2-hydroxynitrobenzene 

Downstream Products

• 352556-22-0 S-(2-aminophenyl)-N,N-dimethylthiocarbamate 
• 4875-10-9 o-nitrothiophenol 
• 352556-36-6 S-[2-(N-benzyl-N-3'-p-tolyl-prop-2'-ynyl)aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-25-3 S-[2-{(N-3'-(1-naphthyl)prop-2'-ynyl)}aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-26-4 S-[2-{(N-3'-(2-naphthyl)prop-2'-ynyl)}aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-33-3 S-[2-{N-3'-(4-iodophenyl)prop-2'-ynyl}aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-34-4 S-[2-{N-3'-(2-iodophenyl)prop-2'-ynyl}aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-32-2 S-[2-{N-3'-(5-iodo-2-thienyl)prop-2'-ynyl}aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-30-0 S-[2-{N-3'-(4-methoxyphenyl)prop-2'-ynyl}aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-28-6 S-[2-(N-3'-o-tolylprop-2'-ynyl)aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-35-5 S-[2-(N-methyl-N-3'-p-tolyl-prop-2'-ynyl)aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-27-5 S-[2-(N-3'-m-chlorophenylprop-2'-ynyl)aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-29-7 S-[2-(N-3'-p-tolylprop-2'-ynyl)aminophenyl]-N,N-dimethylthiocarbamate 
• 352556-31-1 S-[2-{N-3'-(2-thienyl)prop-2'-ynyl}aminophenyl]-N,N-dimethylthiocarbamate 

Relevant academic research and scientific papers

The importance of agitation and fill volume in small scale scientific microwave reactors

The effect of agitation and fill volume in a microwave tube on the rate of homogenous reaction solutions under both stirred and unstirred conditions is reported. Significant increases in rate are found in two different microwave instruments when the homog

Microwave-mediated Newman-Kwart rearrangement in water

For the first time the unimolecular Newman-Kwart rearrangement is performed in pure water. The elevated temperatures required for the 1,3-aryl shift are easily accomplished by microwave irradiation. Differently functionalized substrates underline the expe

A comparison of commercial microwave reactors for scale-up within process chemistry

Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman-Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.

The Newman-Kwart rearrangement: A microwave kinetic study

(Chemical Equation Presented) The kinetic profile of the Newman-Kwart rearrangement has been evaluated using microwave heating. After first demonstrating equivalence between conventional convective heating and microwave heating, data was gathered and anal

Scaling-out pharmaceutical reactions in an automated stop-flow microwave reactor

Six pharmaceutically relevant reactions were assessed for scaleout in an automated stop-flow microwave reactor. Daily throughputs of between 50 and 250 g were achieved at typical reaction concentrations; for more concentrated reactions, or with 24 h proce

The Newman-Kwart rearrangement re-evaluated by microwave synthesis

The Newman-Kwart rearrangement (NKR) has been re-evaluated by microwave heating. Microwave technology has proven to be ideal for investigating this high temperature rearrangement and facilitated the confirmation of many aspects of this valuable reaction.

Application of microreactor technology in process development

The microreactor technology is an efficient tool for kilogram-scale syntheses in continuous mode and is particularly effective for hazardous reactions that do not allow scale-up in conventional reactors. Applications to several classes of reactions including highly exothermic reactions, high-temperature reactions, reactions with unstable intermediates, and reactions involving hazardous reagents are described herein.